Wang Dongdong, Shi Ruohong, Zhou Jiajia, Shi Sixiang, Wu Huihui, Xu Pengping, Wang Hui, Xia Guoliang, Barnhart Todd E, Cai Weibo, Guo Zhen, Chen Qianwang
Hefei National Laboratory for Physical Science at Microscale and Department of Materials Science & Engineering, University of Science & Technology of China, Hefei, Anhui 230026, PR China.
Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, School of Life Sciences, University of Science & Technology of China, Hefei, Anhui 230026, PR China.
iScience. 2018 Nov 30;9:14-26. doi: 10.1016/j.isci.2018.10.005. Epub 2018 Oct 12.
Therapeutic effects of photodynamic therapy (PDT) remain largely limited because of tumor hypoxia. Herein, we report safe and versatile nanocatalysts (NCs) for endogenous oxygen generation and imaging-guided enhanced PDT. The NCs (named as PSP) are prepared by coating Prussian blue (PB) with mesoporous silica to load photosensitizer (zinc phthalocyanine, ZnPc), followed by the modification of polyethylene glycol chains. The inner PB not only acts like a catalase for hydrogen peroxide decomposition but also serves as a photothermal agent to increase the local temperature and then speed up the oxygen supply under near-infrared irradiation. The loaded ZnPc can immediately transform the formed oxygen to generate cytotoxic singlet oxygen upon the same laser irradiation due to the overlapped absorption between PB and ZnPc. Results indicate that the PSP-ZnPc (PSPZP) NCs could realize the photothermally controlled improvement of hypoxic condition in cancer cells and tumor tissues, therefore demonstrating enhanced cancer therapy by the incorporation of PDT and photothermal therapy.
由于肿瘤缺氧，光动力疗法（PDT）的治疗效果在很大程度上仍然有限。在此，我们报告了用于内源性氧气生成和成像引导增强型光动力疗法的安全且通用的纳米催化剂（NCs）。这些纳米催化剂（命名为PSP）是通过用介孔二氧化硅包覆普鲁士蓝（PB）以负载光敏剂（锌酞菁，ZnPc），然后修饰聚乙二醇链制备而成。内部的PB不仅像过氧化氢分解的过氧化氢酶一样起作用，还作为光热剂来提高局部温度，进而在近红外照射下加速氧气供应。由于PB和ZnPc之间的吸收重叠，负载的ZnPc在相同激光照射下可立即将生成的氧气转化为具有细胞毒性的单线态氧。结果表明，PSP-ZnPc（PSPZP）纳米催化剂可以实现癌细胞和肿瘤组织中缺氧状况的光热控制改善，因此通过结合光动力疗法和光热疗法证明了增强的癌症治疗效果。
