NEUROcom, School of Health Sciences University of A Coruna, and Agrupación estratégica CICA-INIBIC - UdC, A Coruna, Spain.
Laboratorio de Neurofisiología Experimental, Hospital Nacional de Parapléjicos, Servicio de Salud de Castilla-La Mancha, Toledo, Spain.
Sci Rep. 2018 Oct 30;8(1):15985. doi: 10.1038/s41598-018-33808-x.
Increasing evidence indicates that static magnetic fields (SMF) reduce cortical activity in both human and animal models. The aim of this work was to investigate the effect of SMF on epileptiform cortical activity, a condition related to an abnormal increase in neuronal excitability. The first experimental block included a Pilocarpine rat model of epilepsy, in which a magnetic neodymium nickel-plated cylinder, a magnetic field of 0.5 T, or "sham" were placed over the skull. In the second experimental block, we recorded epileptic-like activity in the visual cortex of a monkey (Macaca mulatta) under control conditions and in the presence of the magnet. Between 15 and 30 minutes after the second dose of Pilocarpine, EEG changes compatible with seizure like events induced by Pilocarpine were clearly observed in the control animals (sham stimulation). Similar effects were visible in the animals exposed to the real magnet after 1-2 hours. In the monkey, SMF over the cortical focus clearly reduced abnormal activity: the intensity threshold for visual induction increased and the severity and duration decreased. These results reinforce the view that static magnets modulate cortical activity and open the door to the future therapeutic use of SMF in epilepsy as a complement to current pharmacological treatments.
越来越多的证据表明，静磁场（SMF）可降低人类和动物模型的皮质活动。本工作旨在研究 SMF 对癫痫样皮质活动的影响，这种情况与神经元兴奋性异常增加有关。第一个实验块包括匹罗卡品大鼠癫痫模型，在此模型中，在颅骨上放置钕镍镀磁圆柱体，磁场强度为 0.5T 或“假”磁体。在第二个实验块中，我们记录了猴子（猕猴）视觉皮层在对照条件和存在磁体下的癫痫样活动。在第二次给予匹罗卡品后 15 至 30 分钟，在对照动物（假刺激）中清楚地观察到与匹罗卡品诱导的癫痫样事件一致的 EEG 变化。在暴露于真实磁铁 1-2 小时后的动物中也可以看到类似的效果。在猴子中，皮质焦点上的静磁场明显降低了异常活动：视觉诱发的强度阈值增加，严重程度和持续时间减少。这些结果强化了静磁场调节皮质活动的观点，并为未来将静磁场作为当前药物治疗的补充用于癫痫治疗开辟了道路。
