Gray F, Gherardi R, Baudrimont M, Gaulard P, Meyrignac C, Vedrenne C, Poirier J
Acta Neuropathol. 1987;73(1):99-104. doi: 10.1007/BF00695508.
A 29-year-old homosexual male with AIDS presented with progressive encephalopathy and cytomegalovirus (CMV) pneumonia. Neuropathological examination revealed toxoplasma abscesses in corpus callosum, basal ganglia and cerebellar white matter; demyelinating foci in the parietal white matter, with microscopic changes typical of progressive multifocal leucoencephalopathy and intranuclear papovavirus inclusions in oligodendrocytes; and lesions of subacute encephalitis in the periventricular regions with large cells positive by immunostaining for CMV. Diffuse myelin loss was observed in the cerebral white matter. Multinucleated giant cells were numerous in the demyelinated areas, they were also observed in close relationship with papova, CMV and Toxoplasma lesions. Immunostaining of these cells was positive for histiocyte markers and negative with the leucocyte common antigen monoclonal antibody. Some of them contained virus-like particles measuring around 100 nm similar to human immune deficiency virus (HIV) as observed in human brain.
一名29岁患有艾滋病的同性恋男性出现进行性脑病和巨细胞病毒（CMV）肺炎。神经病理学检查发现胼胝体、基底神经节和小脑白质有弓形虫脓肿；顶叶白质有脱髓鞘病灶，具有进行性多灶性白质脑病的典型微观变化以及少突胶质细胞中的核内乳头多瘤空泡病毒包涵体；脑室周围区域有亚急性脑炎病变，通过CMV免疫染色可见大细胞呈阳性。在脑白质中观察到弥漫性髓鞘脱失。在脱髓鞘区域多核巨细胞很多，在与乳头多瘤空泡病毒、CMV和弓形虫病变密切相关处也可观察到多核巨细胞。这些细胞的免疫染色对组织细胞标志物呈阳性，而对白细胞共同抗原单克隆抗体呈阴性。其中一些细胞含有大小约100纳米类似于人类免疫缺陷病毒（HIV）的病毒样颗粒，如同在人脑观察到的那样。
