Cancer Research Center of Lyon (CRCL), UMR Inserm 1052 CNRS 5286 Mixte CLB, Université de Lyon 1 (UCBL1), 69003 Lyon, France.
Inserm, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, 67000 Strasbourg, France.
Viruses. 2018 Oct 30;10(11):591. doi: 10.3390/v10110591.
Hepatitis C virus (HCV) infection is a worldwide health problem and is one of the main causes of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). Despite recent improvements, effective treatments for HCC are still missing and new tools for early detection are needed. Non-coding RNAs (ncRNAs) have emerged as important regulators of gene expression and key players in human carcinogenesis, including HCC. Aberrant expression of ncRNAs is associated with HCC metastasis, invasion, dissemination, and recurrence. This review will focus on the recent advances in ncRNA expression profiles, their dysregulation in HCV-related HCC, and the clinical perspective of ncRNA signatures for the early detection of HCC.
丙型肝炎病毒（HCV）感染是一个全球性的健康问题，也是慢性肝炎、肝硬化和肝细胞癌（HCC）的主要原因之一。尽管最近有所改善，但 HCC 的有效治疗方法仍然缺乏，需要新的早期检测工具。非编码 RNA（ncRNA）已成为基因表达的重要调节剂和人类肿瘤发生的关键因素，包括 HCC。ncRNA 的异常表达与 HCC 的转移、侵袭、扩散和复发有关。本综述将重点介绍 ncRNA 表达谱的最新进展、它们在 HCV 相关 HCC 中的失调，以及 ncRNA 特征在 HCC 早期检测中的临床意义。
