玫瑰茄对过度训练大鼠血浆和海马中白细胞介素-1β/白细胞介素-1受体拮抗剂比值的抗炎作用及其与空间记忆的相关性
Anti-inflammatory Effects of Hibiscus Sabdariffa Linn. on the IL-1β/IL-1ra Ratio in Plasma and Hippocampus of Overtrained Rats and Correlation with Spatial Memory.
作者信息
Bayani Gulshan Fahmi El, Marpaung Nurasi Lidya E, Simorangkir Dedy Arnold Sastrajaya, Sianipar Imelda Rosalyn, Ibrahim Nurhadi, Kartinah Neng Tine, Mansur Indra Gusti, Purba Jan S, Ilyas Ermita I Ibrahim
机构信息
Biomedical Science Master Program Student-Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
Department of Medical Physiology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
出版信息
Kobe J Med Sci. 2018 Oct 15;64(2):E73-E83.
Overtraining leads to an increase in IL-1β systemically due to muscle microtrauma, which affects the hippocampus, an important structure in spatial memory consolidation. The administration of Hibiscus sabdariffa Linn is expected to decrease IL-1β and increase IL-1ra, thereby potentially preventing impairments in spatial memory consolidation. This research was an experimental study using 20 male Wistar rats. The overtraining of Wistar rats altered the ratio of IL-1β/IL-1ra in the plasma and hippocampus. Moreover, this overtraining impaired spatial memory consolidation. The methanol extract of H. sabdariffa improved spatial memory consolidation in Wistar rats and prevented impairment in spatial memory consolidation by maintaining the ratio of IL-1β/IL-1ra in the plasma and hippocampus of Wistar rats who experienced overtraining. H. sabdariffa is a potent anti-inflammatory substance that prevents impairments in spatial memory consolidation in overtrained Wistar rats.
过度训练会由于肌肉微创伤导致全身白细胞介素-1β（IL-1β）增加，这会影响海马体，而海马体是空间记忆巩固中的一个重要结构。木槿（Hibiscus sabdariffa Linn）的施用有望降低IL-1β并增加白细胞介素-1受体拮抗剂（IL-1ra），从而有可能预防空间记忆巩固受损。本研究是一项使用20只雄性Wistar大鼠的实验研究。Wistar大鼠的过度训练改变了血浆和海马体中IL-1β/IL-1ra的比例。此外，这种过度训练损害了空间记忆巩固。木槿的甲醇提取物改善了Wistar大鼠的空间记忆巩固，并通过维持经历过度训练的Wistar大鼠血浆和海马体中IL-1β/IL-1ra的比例来预防空间记忆巩固受损。木槿是一种有效的抗炎物质，可预防过度训练的Wistar大鼠的空间记忆巩固受损。
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