Macquart-Moulin G, Riboli E, Cornée J, Kaaks R, Berthezène P
Int J Cancer. 1987 Aug 15;40(2):179-88. doi: 10.1002/ijc.2910400209.
This study investigates the differences in usual past diet between 252 subjects with newly diagnosed adenomatous or villous polyps of the colon and rectum and a group of 238 hospital controls. Cases and controls were interviewed in hospital by 3 nutritionists using a dietary history questionnaire focused on the diet during the preceding year. Nutrient intake was estimated by means of ad hoc food tables adapted from French and British tables. Out of 16 food groups considered in the analyses, the cases reported lower consumption of oil and potatoes and higher consumption of sugar added to food and drink. Among nutrients, we found that cases had a lower consumption of carbohydrates (not taking into account added sugar), potassium, magnesium and vitamin B6. We found a slightly lower intake of fibre and a slightly higher intake of saturated fat among cases, though neither was statistically significant. Intake values for fibre and for carbohydrates were highly intercorrelated and, due to measurement errors, the effect of one may be masked by the other and vice versa. The hypothesis that some components of carbohydrates (starches, fibre and natural sugars but not added sugar) play a protective role in relation to the biology of tumours of the intestinal tract is considered in further multivariate analyses and in the "Discussion".
本研究调查了252名新诊断为结肠和直肠腺瘤性或绒毛状息肉的受试者与238名医院对照者之间既往日常饮食的差异。病例组和对照组在医院由3名营养学家进行访谈，使用一份侧重于前一年饮食的饮食史问卷。营养素摄入量通过改编自法国和英国食物表的专用食物表进行估算。在分析中考虑的16个食物组中，病例组报告食用油和土豆的消费量较低，而添加到食物和饮料中的糖的消费量较高。在营养素方面，我们发现病例组碳水化合物（不包括添加糖）、钾、镁和维生素B6的消费量较低。我们发现病例组的纤维摄入量略低，饱和脂肪摄入量略高，不过两者均无统计学意义。纤维和碳水化合物的摄入量值高度相关，并且由于测量误差，其中一个的影响可能会被另一个掩盖，反之亦然。碳水化合物的某些成分（淀粉、纤维和天然糖，但不包括添加糖）对肠道肿瘤生物学具有保护作用这一假设将在进一步的多变量分析和“讨论”中进行探讨。
