α2,3- 和 α2,6-唾液乳糖通过受体介导的内吞作用和吞噬作用增强细菌清除。
Bacterial Clearance Is Enhanced by α2,3- and α2,6-Sialyllactose via Receptor-Mediated Endocytosis and Phagocytosis.
机构信息
Division of Systems Biology and Bioengineering, South Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology, Daejeon, Republic of Korea.
出版信息
Infect Immun. 2018 Dec 19;87(1). doi: 10.1128/IAI.00694-18. Print 2019 Jan.
Sialyllactose (SL) is a representative human milk oligosaccharide (HMO) of human breast milk. The roles of SL in infant brain development and immunity have been reported in previous studies. In this study, we identified the impact of SL on innate immunity. Our results showed that the administration of SL had significant efficacy on bacterial clearance in K-infected mice. We also examined the role of SL in the human THP-1 macrophage-like cell line. SL effectively promoted receptor-mediated endocytosis and phagocytosis. Furthermore, SL accelerated the recruitment of Rac1 to the cell membrane, leading to the generation of reactive oxygen species for the elimination of phagocytosed bacteria. Our findings provide a new perspective on the role of SL in breast milk and suggest its application as a therapeutic agent to treat bacterial and viral infections.
唾液乳糖（SL）是母乳中具有代表性的人乳寡糖（HMO）之一。先前的研究报道了 SL 在婴儿大脑发育和免疫力方面的作用。在本研究中，我们确定了 SL 对固有免疫的影响。结果表明，SL 给药对 K 感染小鼠的细菌清除具有显著疗效。我们还研究了 SL 在人 THP-1 巨噬样细胞系中的作用。SL 可有效促进受体介导的内吞作用和吞噬作用。此外，SL 加速了 Rac1 向细胞膜的募集，从而产生活性氧以清除吞噬的细菌。我们的研究结果为 SL 在母乳中的作用提供了新的视角，并提示其作为治疗细菌和病毒感染的治疗剂的应用。
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