3' 端尿苷酸化在 RNA 代谢和细胞生理学中的作用。
The role of 3' end uridylation in RNA metabolism and cellular physiology.
机构信息
Central European Institute of Technology (CEITEC), Masaryk University, Kamenice 5/A35, Brno 625 00, Czech Republic.
Central European Institute of Technology (CEITEC), Masaryk University, Kamenice 5/A35, Brno 625 00, Czech Republic
出版信息
Philos Trans R Soc Lond B Biol Sci. 2018 Nov 5;373(1762):20180171. doi: 10.1098/rstb.2018.0171.
Most eukaryotic RNAs are posttranscriptionally modified. The majority of modifications promote RNA maturation, others may regulate function and stability. The 3' terminal non-templated oligouridylation is a widespread modification affecting many cellular RNAs at some stage of their life cycle. It has diverse roles in RNA metabolism. The most prevalent is the regulation of stability and quality control. On the cellular and organismal level, it plays a critical role in a number of pathways, such as cell cycle regulation, cell death, development or viral infection. Defects in uridylation have been linked to several diseases. This review summarizes the current knowledge about the role of the 3' terminal oligo(U)-tailing in biology of various RNAs in eukaryotes and describes key factors involved in these pathways.This article is part of the theme issue '5' and 3' modifications controlling RNA degradation'.
大多数真核 RNA 都经过转录后修饰。大多数修饰促进 RNA 的成熟，而其他修饰可能调节功能和稳定性。3'末端非模板寡尿苷酸化是一种广泛存在的修饰，在其生命周期的某些阶段影响许多细胞 RNA。它在 RNA 代谢中具有多种作用。最常见的是调节稳定性和质量控制。在细胞和机体水平上，它在许多途径中发挥着关键作用，如细胞周期调控、细胞死亡、发育或病毒感染。尿苷酸化缺陷与多种疾病有关。这篇综述总结了 3'末端寡(U)尾在真核生物各种 RNA 生物学中的作用的最新知识，并描述了这些途径中涉及的关键因素。本文是“5'和 3'修饰控制 RNA 降解”主题特刊的一部分。
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