Andersson U, Martinez-Maza O, Andersson J, Britton S, Gadler H, De Ley M, Modrow S
Scand J Immunol. 1984 Nov;20(5):425-32. doi: 10.1111/j.1365-3083.1984.tb01021.x.
Using a haemolytic plaque assay for gamma-interferon (IFN-gamma) secretion we found that in vitro Epstein-Barr virus (EBV) exposure of peripheral blood mononuclear cells from EBV immune individuals led to IFN-gamma secretion, which was apparent within 6 h after virus contact and peaked 12-24 h after induction. Live, ultraviolet-light-irradiated and heat-inactivated virions all caused IFN-gamma secretion. In contrast, blood mononuclear cells from EBV non-immune adults or neonates could not be activated to IFN-gamma production by EBV.
利用溶血空斑试验检测γ干扰素（IFN-γ）分泌，我们发现，来自EB病毒免疫个体的外周血单个核细胞在体外暴露于EB病毒（EBV）后会导致IFN-γ分泌，这在病毒接触后6小时内即可显现，并在诱导后12 - 24小时达到峰值。活病毒、紫外线照射病毒和热灭活病毒均能引起IFN-γ分泌。相比之下，来自EBV非免疫成人或新生儿的血液单个核细胞不能被EBV激活产生IFN-γ。
