George Washington University School of Medicine & Health Sciences, Washington, District of Columbia.
Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, Washington.
Am J Trop Med Hyg. 2018 Nov;99(5):1342-1345. doi: 10.4269/ajtmh.17-0836.
We sought to compare seroprevalence of protective measles and rubella-specific antibody in mother-infant pairs across two populations: a pre-disease elimination Nepal population with recently introduced rubella vaccine and post-disease elimination U.S. population. Qualitative measles and rubella immunoglobulin G was assessed in maternal serum and cord blood from 258 pairs in Nepal, 2012-2013 and 49 pairs in Seattle, WA, 2014-2015. High rates of protective antibody were observed in both populations. Two hundred and forty-four (95%) pregnant women in Nepal had protective measles antibody versus 44 (92%) in Seattle ( = 0.42). Ninety-six percent of infants in Nepal ( = 246) and Seattle ( = 43) had protective measles antibody ( = 0.75). Ninety-four percentage of pregnant women in Nepal ( = 242) and Seattle ( = 45) had protective rubella antibody ( = 0.23). Two hundred and thirty-eight (93%) infants in Nepal had protective rubella antibody versus 44 (98%) in Seattle ( = 0.12). Continued surveillance will be necessary to ensure protective immunity, inform progress toward disease elimination in Nepal and avoid reemergence in the United States.
一个是尼泊尔消除疾病前人群，引入风疹疫苗不久；另一个是美国消除疾病后人群。2012-2013 年在尼泊尔的 258 对母婴和 2014-2015 年在西雅图的 49 对母婴中定性评估了母体血清和脐血中的麻疹和风疹免疫球蛋白 G。在两个地区都观察到了高比例的保护性抗体。尼泊尔 244 名（95%）孕妇有麻疹保护性抗体，西雅图为 44 名（92%）（ = 0.42）。尼泊尔 246 名（96%）婴儿（ = 43）和西雅图（ = 75）有麻疹保护性抗体（ = 0.75）。尼泊尔 242 名（94%）孕妇（ = 45）和西雅图（ = 23）有风疹保护性抗体（ = 0.23）。尼泊尔 238 名（93%）婴儿有风疹保护性抗体，西雅图为 44 名（98%）（ = 0.12）。需要持续监测以确保保护性免疫，为尼泊尔消除疾病的进展提供信息，并避免在美国重新出现。
