Yin Xueqian, Wen Ya, Li Yajing, Liu Pengqing, Li Zhongming, Shi Yidong, Lan Jianwu, Guo Ronghui, Tan Lin
College of Light Industry, Textile and Food Engineering, Sichuan University, Chengdu, China.
College of Architecture & Environment, Sichuan University, Chengdu, China.
Front Chem. 2018 Oct 16;6:490. doi: 10.3389/fchem.2018.00490. eCollection 2018.
A common problem existing in wound dressing is to integrate the properties of against water erosion while maintaining a high water-uptake capacity. To tackle this issue, we imbedded one layer of hydrogel nanofibrous mat into two hydrophobic nanofibrous mats, thereafter, the sandwich structural membrane (SSM) was obtained. Particularly, SSM is composed of three individual nanofibrous layers which were fabricated through sequential electrospinning technology, including two polyurethane/antibacterial agent layers, and one middle gelatin/rutin layer. The obtained SSM is characterized in terms of morphology, component, mechanical, and functional performance. In addition to the satisfactory antibacterial activity against and , and antioxidant property upon scavenging DPPH free radicals, the obtained SSM also shows a desirable thermally regulated water vapor transmission rate. More importantly, such SSM can be mechanically stable and keep its intact morphology without appearance damage while showing a high water-absorption ratio. Therefore, the prepared sandwich structural membrane with hydrogel nanofibrous mat as inner layer can be expected as a novel wound dressing.
伤口敷料中存在的一个常见问题是在保持高吸水能力的同时兼具抗水侵蚀的特性。为了解决这个问题，我们将一层水凝胶纳米纤维垫嵌入两层疏水性纳米纤维垫中，从而获得了三明治结构膜（SSM）。特别地，SSM由三个单独的纳米纤维层组成，这些层是通过连续静电纺丝技术制备的，包括两个聚氨酯/抗菌剂层和一个中间的明胶/芦丁层。对所得的SSM进行了形态、成分、力学和功能性能方面的表征。除了对[具体细菌名称1]和[具体细菌名称2]具有令人满意的抗菌活性以及清除DPPH自由基的抗氧化性能外，所得的SSM还显示出理想的热调节水蒸气透过率。更重要的是，这种SSM在机械上是稳定的，能保持其完整的形态而无外观损伤，同时具有高吸水率。因此，所制备的以内层为水凝胶纳米纤维垫的三明治结构膜有望成为一种新型伤口敷料。
