Santa Barbara Primary Care Centre, Castilla-La Mancha Health Service, Esparteros 6, E-45006 Toledo, Spain.
Primary Care Research Unit of Bizkaia, Basque Health Service (BHS), Luis Power 18, E-48014 Bilbao, Spain.
Prev Med. 2019 Jan;118:232-237. doi: 10.1016/j.ypmed.2018.10.020. Epub 2018 Nov 8.
Both, cardiorespiratory fitness and abdominal obesity are independently associated with developing cardiovascular disease and its risk factors. However, the relationship between both attributes is unclear. We examine the relationship between cardiorespiratory fitness and the risk of developing abdominal obesity, and secondarily, other adiposity measures. Retrospective observational study of a cohort of 1284 sedentary patients, who had participated in a clinical trial of physical activity promotion carried out in Spain (2003-2007). At baseline, they were free of cardiovascular disease, hypertension, diabetes, dyslipidemia and/or abdominal obesity, with an indirect VOmax measurement, were 19-80 years old, 62% women, and had completed the two year follow-up. The exposure factor was cardiorespiratory fitness categorized as high, moderate or low, according to tertiles of VOmax values. The main outcome measure was the risk of developing abdominal obesity, as defined by waist circumference >102 (men) and >88 (women) cm. Secondary outcomes were the risk of developing: general obesity, excess body fat, and their combination ("defined" obesity). At two years, 10.5% of the participants had developed abdominal obesity: 6.1% in the high cardiorespiratory fitness tertile, 9.7% in the moderate tertile (adjusted odds ratio, 1.20; 95% confidence interval 0.68-2.10), and 15.7% in the low tertile (adjusted odds ratio, 2.29; 95% confidence interval 1.34-3.91). Moreover, 2.2% of participants in the high cardiorespiratory fitness tertile developed "defined" obesity as did 5.4% in the low tertile (adjusted odds ratio, 2.90; 95% confidence interval 1.15-7.29). Low cardiorespiratory fitness levels are associated with a higher risk of developing abdominal and "defined" obesity.
心肺适能和腹型肥胖均与心血管疾病及其危险因素的发生独立相关。然而，两者之间的关系尚不清楚。我们研究了心肺适能与腹型肥胖发生风险的关系，其次，还研究了其他肥胖测量指标。这是一项在西班牙进行的身体活动促进临床试验队列的回顾性观察研究（2003-2007 年）。基线时，所有患者均无心血管疾病、高血压、糖尿病、血脂异常和/或腹型肥胖，通过间接 VOmax 测量，年龄在 19-80 岁之间，62%为女性，并完成了两年的随访。暴露因素是心肺适能，根据 VOmax 值的三分位数分为高、中、低水平。主要结局指标是腹型肥胖的发病风险，定义为腰围男性>102cm、女性>88cm。次要结局指标是发生：全身肥胖、体脂过多，以及两者的组合（“定义”肥胖）的风险。两年后，10.5%的参与者发生了腹型肥胖：高心肺适能三分位组 6.1%，中三分位组 9.7%（调整后的优势比，1.20；95%置信区间 0.68-2.10），低三分位组 15.7%（调整后的优势比，2.29；95%置信区间 1.34-3.91）。此外，高心肺适能三分位组有 2.2%的参与者发生了“定义”肥胖，低三分位组有 5.4%（调整后的优势比，2.90；95%置信区间 1.15-7.29）。低心肺适能水平与腹型和“定义”肥胖的发生风险增加相关。
