Department of Ceramic Engineering, IIT (BHU), Varanasi 221005, India; School of Materials Science & Technology, IIT (BHU), Varanasi 221005, India..
School of Materials Science & Technology, IIT (BHU), Varanasi 221005, India..
Mater Sci Eng C Mater Biol Appl. 2019 Jan 1;94:279-290. doi: 10.1016/j.msec.2018.09.041. Epub 2018 Sep 13.
Strontium based bioactive glasses have shown a better biocompatibility than calcia based bioactive glasses. In this report, we have shown that the bioactivity is found to be even more when we incorporate AlO upto 1.5 mol% in SiO-CaO-PO-SrO bioactive glass. We have studied the structural, physico-mechanical and bioactive properties in these glasses with varying alumina concentration from 0.5 to 2.5 mol%. The bioactivity of the glasses is evaluated by in vitro test in simulated body fluid (SBF). The formation of hydroxy carbonated apatite layer (HCA) on the surface of glasses after immersion in SBF is identified by the XRD, FTIR and SEM. The substitution of AlO for SrO in these glasses demonstrates a significant enhancement in compressive strength and elastic modulus. However cytotoxicity and cell viability assessed using human osteosarcoma U2-OS cell lines show the growth of the cells without causing any significant loss of viability and cell death upto 1.5 mol% addition of AlO. Osteosarcoma cells grow on the surface of bioglasses which make them biocompatible and fit for use in clinical trials.
基于锶的生物活性玻璃比基于钙的生物活性玻璃具有更好的生物相容性。在本报告中，我们表明，当我们将 AlO 掺入到 SiO-CaO-PO-SrO 生物活性玻璃中高达 1.5 mol%时，生物活性变得更高。我们研究了这些玻璃在不同氧化铝浓度（0.5 至 2.5 mol%）下的结构、物理机械和生物活性性能。通过在模拟体液（SBF）中的体外测试来评估玻璃的生物活性。将玻璃浸泡在 SBF 后，表面形成羟基碳酸磷灰石层（HCA），可通过 XRD、FTIR 和 SEM 来识别。在这些玻璃中，AlO 取代 SrO 表现出抗压强度和弹性模量的显著提高。然而，使用人骨肉瘤 U2-OS 细胞系评估细胞毒性和细胞活力表明，细胞在没有造成任何显著活力损失和细胞死亡的情况下生长，AlO 的添加量高达 1.5 mol%。骨肉瘤细胞在生物玻璃表面生长，使它们具有生物相容性，适合临床试验使用。
