Karakuzu-Ikizler Burcu, Terzioğlu Pınar, Basaran-Elalmis Yeliz, Tekerek Bilge Sema, Yücel Sevil
Department of Bioengineering, Faculty of Chemistry and Metallurgy, Yildiz Technical University, Istanbul, Turkey.
Department of Fiber and Polymer Engineering, Faculty of Engineering and Natural Sciences, Bursa Technical University, Bursa, Turkey.
Bioact Mater. 2020 Jan 13;5(1):66-73. doi: 10.1016/j.bioactmat.2019.12.007. eCollection 2020 Mar.
The objective of this study was to investigate the effect of magnesium (1 wt%) and aluminum (1 wt%) incorporation on the bioactivity and biodegradation behavior of 45S5 bioactive glasses synthesized from rice husk biogenic silica. The performance of biogenic silica-based samples was compared well with commercial silica-based counterparts. The biodegradation behavior of bioactive glasses was evaluated by the weight loss of samples and pH variation in the Tris buffer solution. Based on composition, bioglasses possessed different properties before and after simulated body fluid (SBF) immersion. The incorporation of magnesium (Mg) and aluminum (Al) enhanced the Vickers hardness of bioglasses. All the bioglasses showed the hydroxyapatite layer formation after SBF treatment as confirmed by the dissolution, FTIR, SEM and XRD analysis, however it was more prominent in the rice husk silica-based 45S5 bioglass. The biogenic silica seems to be a promising starting material for bioglass systems to be used in bone tissue engineering applications.
本研究的目的是研究掺入1 wt%的镁和1 wt%的铝对由稻壳生物源二氧化硅合成的45S5生物活性玻璃的生物活性和生物降解行为的影响。基于生物源二氧化硅的样品的性能与商业二氧化硅基对应物相比表现良好。通过样品的重量损失和Tris缓冲溶液中的pH变化来评估生物活性玻璃的生物降解行为。基于组成，生物玻璃在模拟体液（SBF）浸泡前后具有不同的性能。镁（Mg）和铝（Al）的掺入提高了生物玻璃的维氏硬度。经溶解、傅里叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）和X射线衍射（XRD）分析证实，所有生物玻璃在SBF处理后均形成了羟基磷灰石层，然而在基于稻壳二氧化硅的45S5生物玻璃中更为明显。生物源二氧化硅似乎是用于骨组织工程应用的生物玻璃系统的一种有前途的起始材料。
