Zhang Haiqing, Li Yuqian, Mao Zhenxing, Liu Min, Huo Wenqian, Liu Ruihua, Liu Xiaotian, Tu Runqi, Yang Kaili, Qian Xinling, Jiang Jingjing, Zhang Xia, Tian Zhongyan, Bie Ronghai, Wang Chongjian
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China.
Department of Clinical Pharmacology, School of Pharmaceutical Science, Zhengzhou University, Zhengzhou, Henan, PR China.
J Am Soc Hypertens. 2018 Dec;12(12):867-879.e3. doi: 10.1016/j.jash.2018.10.005. Epub 2018 Oct 24.
The purpose of the study was to determine if there was a relationship between night sleep duration and hypertension, and to evaluate as to whether blood lipid levels played a role in this relationship. A total of 37,317 participants aged 18-79 years were included in this study. Night sleep duration was classified as <5, 5-, 6-, 7-, 8-, 9-, and ≥10 hours. Logistic regression and restricted cubic spline analysis was carried out to evaluate the association of sleep duration with hypertension. Compared with reference sleep duration (7 hours), in males, the multivariate odds ratios (ORs) (95% confidence interval [95% CI]) of the groups with longest sleep duration (≥10 hours) and shortest sleep duration (<5 hours) for hypertension was 1.52 (1.25-1.84) and 1.07 (0.80-1.44), respectively. Similarly, the longest sleep duration was associated with diagnosed hypertension (1.21, 1.00-1.45) in females. The OR for an indirect effect of sleep duration through low-density lipoprotein cholesterol (LDL-C) on hypertension was 1.085 (95% CI 1.038-1.137). Overall, a 3.5% possibility of hypertension being associated with sleep duration was attributable to LDL-C. In summary, a relationship between sleep duration and hypertension was observed in this rural population. LDL-C appeared to partially mediate the effect of sleep duration on hypertension in males.
该研究的目的是确定夜间睡眠时间与高血压之间是否存在关联，并评估血脂水平在这种关联中是否起作用。本研究共纳入了37317名年龄在18至79岁之间的参与者。夜间睡眠时间被分类为<5小时、5至<6小时、6至<7小时、7至<8小时、8至<9小时、9至<10小时以及≥10小时。进行了逻辑回归和受限立方样条分析以评估睡眠时间与高血压的关联。与参考睡眠时间（7小时）相比，在男性中，睡眠时间最长（≥10小时）和最短（<5小时）的组患高血压的多因素比值比（OR）（95%置信区间[95%CI]）分别为1.52（1.25至1.84）和1.07（0.80至1.44）。同样，在女性中，最长睡眠时间与确诊高血压相关（1.21，1.00至1.45）。通过低密度脂蛋白胆固醇（LDL-C）介导的睡眠时间对高血压的间接效应的OR为1.085（95%CI 1.038至1.137）。总体而言，高血压与睡眠时间相关的可能性中有3.5%可归因于LDL-C。总之，在这一农村人群中观察到了睡眠时间与高血压之间的关联。LDL-C似乎部分介导了睡眠时间对男性高血压的影响。
