类风湿性关节炎患者尿液中胶原羟基吡啶交联物的排泄情况。
Urinary excretion of the hydroxypyridinium cross links of collagen in patients with rheumatoid arthritis.
作者信息
Black D, Marabani M, Sturrock R D, Robins S P
机构信息
Rowett Research Institute, Bucksburn, Aberdeen.
出版信息
Ann Rheum Dis. 1989 Aug;48(8):641-4. doi: 10.1136/ard.48.8.641.
Abstract
Values for urinary hydroxypyridinium cross links of collagen measured by high performance liquid chromatography in a group of 19 seropositive patients with rheumatoid arthritis (RA) were compared with 19 controls matched for age and sex. The amounts of pyridinoline, expressed relative to creatinine, were significantly higher in the RA group, but there was no significant increase in a bone specific analogue, deoxypyridinoline. There were significant positive correlations between pyridinoline excretion and both C reactive protein and erythrocyte sedimentation rate, whereas there was an inverse relation with grip strength. The data indicated that pyridinoline concentrations in urine are strongly associated with disease activity in patients with RA.
摘要
通过高效液相色谱法测量了一组19名血清阳性类风湿关节炎（RA）患者尿液中胶原蛋白的羟基吡啶交联物的值，并与19名年龄和性别相匹配的对照组进行了比较。以肌酐为参照，RA组中吡啶啉的含量显著更高，但骨特异性类似物脱氧吡啶啉没有显著增加。吡啶啉排泄量与C反应蛋白和红细胞沉降率均呈显著正相关，而与握力呈负相关。数据表明，RA患者尿液中吡啶啉浓度与疾病活动密切相关。
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本文引用的文献
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