Center for Addiction Research, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555, USA.
Center for Addiction Research, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555, USA; Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555, USA.
Appetite. 2019 Feb 1;133:231-239. doi: 10.1016/j.appet.2018.11.011. Epub 2018 Nov 14.
Binge eating episodes are characterized by uncontrollable, excessive intake of food and are associated with binge eating disorder and some subtypes of obesity. One factor thought to contribute to binge episodes is a high level of reactivity to food-associated cues (i.e., cue reactivity). The insula is a neural node poised to regulate both binge eating and cue reactivity because of its prominent role in interpretation of internal and external cues. This work established a positive association between high fat food (HFF) binge intake and cue reactivity in male rats. Furthermore, we demonstrated that activation of the anterior insula suppressed both HFF binge intake and cue reactivity, without altering homeostatic intake of food. We further show that attenuation of HFF binge intake and cue reactivity is not due to decreased food-reward efficacy or deficits in motivation. Together, these data establish a key role for the anterior insula in the control of binge eating related-behaviors and support novel avenues for the treatment of binge eating.
暴食发作的特点是无法控制地过量摄入食物，与暴食障碍和某些肥胖亚型有关。人们认为导致暴食发作的一个因素是对食物相关线索（即线索反应性）的高度反应性。由于其在解释内部和外部线索方面的突出作用，岛叶是一个调节暴食和线索反应性的神经节点。这项工作在雄性大鼠中建立了高脂肪食物（HFF）暴食摄入与线索反应性之间的正相关关系。此外，我们还证明了前岛叶的激活抑制了 HFF 的暴食摄入和线索反应性，而不会改变食物的稳态摄入。我们进一步表明，HFF 暴食摄入和线索反应性的减弱并不是由于食物奖赏效力降低或动机缺陷所致。总之，这些数据确立了前岛叶在控制与暴食相关行为中的关键作用，并为暴食的治疗提供了新的途径。
