Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Semin Cell Dev Biol. 2018 Dec;84:22-29. doi: 10.1016/j.semcdb.2017.12.002. Epub 2018 Oct 8.
Viruses are intracellular pathogens that cause a vast array of diseases, which are often severe and typified by high morbidity and mortality rates. Viral infections continue to be a global health burden and effective vaccines and therapeutics are constantly sought to prevent and treat these infections. The development of such treatments generally relies on understanding the mechanisms that underpin efficient host antiviral immune responses. This review summarises recent developments in our understanding of antiviral adaptive immunity and in particular, highlights the use of mass spectrometry to elucidate viral antigens and their processing and presentation to T cells and other immune effectors. These processed peptides serve as potential vaccine candidates or may facilitate clinical monitoring, diagnosis and immunotherapy of infectious diseases.
病毒是一种细胞内病原体，可引起多种疾病，这些疾病通常很严重，其特点是发病率和死亡率高。病毒感染仍然是全球健康负担，人们一直在寻求有效的疫苗和疗法来预防和治疗这些感染。这类治疗方法的发展通常依赖于对有效宿主抗病毒免疫反应机制的理解。本综述总结了我们对抗病毒适应性免疫的理解的最新进展，特别是强调了使用质谱法阐明病毒抗原及其加工和呈递给 T 细胞和其他免疫效应物的过程。这些加工后的肽段可作为潜在的疫苗候选物，或有助于传染病的临床监测、诊断和免疫治疗。
