Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Department of Infectious Diseases, Ajou University School of Medicine, Suwon, Korea.
J Korean Med Sci. 2018 Oct 25;33(47):e296. doi: 10.3346/jkms.2018.33.e296. eCollection 2018 Nov 19.
Antepartum, intrapartum, and postpartum preventive measures with antiretroviral drugs, appropriate delivery methods, and discouraging breastfeeding significantly decrease the risk of mother-to-child transmission of human immunodeficiency virus (HIV) infection. Herein, we investigated the pregnancy outcomes in HIV-infected Korean women.
We retrospectively reviewed medical records of childbearing-age HIV-infected women between January 2005 and June 2017 at four tertiary care hospitals in Korea.
Among a total of 95 HIV infected women of child-bearing age with 587.61 years of follow-up duration, 15 HIV-infected women experienced 21 pregnancies and delivered 16 infants. The pregnancy rate was 3.57 per 100 patient-years. Among the 21 pregnancies, five ended with an induced abortion, and 16 with childbirth including two preterm deliveries at 24 and 35 weeks of gestation, respectively. The two preterm infants had low birth weight and one of them died 10 days after delivery due to respiratory failure. Among the 14 full-term infants, one infant was small for gestational age. There were no HIV-infected infants.
The pregnancy rate of HIV-infected women in Korea is lower than that of the general population. Although several adverse pregnancy outcomes were observed, mother-to-child transmission of HIV infection was successfully prevented with effective preventive measures.
通过抗逆转录病毒药物进行产前、产时和产后预防措施，采用适当的分娩方式，并劝阻母乳喂养，可以显著降低人类免疫缺陷病毒（HIV）母婴传播的风险。在此，我们调查了感染 HIV 的韩国女性的妊娠结局。
我们回顾性分析了 2005 年 1 月至 2017 年 6 月在韩国四家三级保健医院就诊的育龄期 HIV 感染女性的病历。
在总共 95 名有生育能力的 HIV 感染女性中，随访时间为 587.61 年，其中 15 名 HIV 感染女性经历了 21 次妊娠，分娩了 16 名婴儿。妊娠率为每 100 患者年 3.57 次。在 21 次妊娠中，有 5 次以人工流产结束，16 次以分娩结束，包括 2 次分别为 24 周和 35 周的早产。这两个早产儿的出生体重较低，其中一个在出生后 10 天因呼吸衰竭死亡。在 14 名足月婴儿中，有 1 名婴儿为小于胎龄儿。没有 HIV 感染的婴儿。
韩国 HIV 感染女性的妊娠率低于普通人群。尽管观察到了一些不良的妊娠结局，但通过有效的预防措施成功地预防了 HIV 母婴传播。
