Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, U.K.
Biochem J. 2018 Nov 20;475(22):3511-3534. doi: 10.1042/BCJ20170677.
The structure and function of glucose transporters of the mammalian GLUT family of proteins has been studied over many decades, and the proteins have fascinated numerous research groups over this time. This interest is related to the importance of the GLUTs as archetypical membrane transport facilitators, as key limiters of the supply of glucose to cell metabolism, as targets of cell insulin and exercise signalling and of regulated membrane traffic, and as potential drug targets to combat cancer and metabolic diseases such as type 2 diabetes and obesity. This review focusses on the use of chemical biology approaches and sugar analogue probes to study these important proteins.
几十年来，人们一直在研究哺乳动物 GLUT 蛋白家族的葡萄糖转运蛋白的结构和功能，这些蛋白质在这段时间里吸引了众多研究小组的关注。这种兴趣与 GLUT 作为典型的膜转运促进剂的重要性有关，作为葡萄糖向细胞代谢供应的关键限制因素，作为细胞胰岛素和运动信号以及调节膜运输的靶点，以及作为潜在的药物靶点，以对抗癌症和代谢疾病，如 2 型糖尿病和肥胖症。本综述重点介绍了使用化学生物学方法和糖类似物探针来研究这些重要蛋白质。
