Comparative Transcriptome Analysis between a Resistant and a Susceptible Wild Tomato Accession in Response to .

is one of the most widespread species, which is known to cause multiple diseases in tomato and is capable of infecting almost all plant parts. Our current understanding of tomato- interaction is very limited and currently nothing is known at the whole genome or transcriptome level. In this study, we have analyzed and compared the transcriptome of a resistant and a susceptible wild tomato accession in response to infection using the RNA-seq technology. We have identified 2657 and 3079 differentially expressed genes (DEGs) in treatment vs control comparison of resistant (Sp-R) and susceptible (Sp-S) samples respectively. Functional annotation of DEGs revealed substantial transcriptional reprogramming of diverse physiological and cellular processes, particularly the biotic stress responses in both Sp-R and Sp-S upon treatment. However, subtle expression differences among some core plant defense related genes were identified and their possible role in resistance development against is discussed. Our results revealed 1173 genes that were differentially expressed only in Sp-R accession upon inoculation. These exclusively found DEGs in Sp-R accession included some core plant defense genes, for example, several protease inhibitors, chitinases, defensin, PR-1, a downy mildew susceptibility factor, and so on, were all highly induced. Whereas, several genes, WRKY transcriptions factors and a powdery mildew susceptibility gene () were highly repressed during the resistance outcome. Analysis reported here lays out a strong foundation for future studies aimed at improving genetic resistance of tomato cultivars against to species.