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调查纽约州胃底折叠术或食管裂孔疝修补术后再次手术或术后胃轻瘫的发生率。

Investigating rates of reoperation or postsurgical gastroparesis following fundoplication or paraesophageal hernia repair in New York State.

机构信息

Division of Bariatric, Foregut and Advanced Gastrointestinal Surgery, Department of Surgery, Stony Brook University Medical Center, Stony Brook, NY, USA.

, Mineola, USA.

出版信息

Surg Endosc. 2019 Sep;33(9):2886-2894. doi: 10.1007/s00464-018-6588-z. Epub 2018 Nov 26.

Abstract

BACKGROUND

Little is known of the natural history of fundoplication or paraesophageal hernia (PEH) repair in terms of reoperation or the incidence treatment of postsurgical gastroparesis (PSG) in large series. Repeat fundoplications or PEH repairs, as well as pyloroplasty/pyloromyotomy operations, have proven to be effective in the context of PSG or recurrence. In this study, we analyzed the incidences of PSG and risk factors for these revisional surgeries following fundoplication and PEH repair procedures in the state of New York.

METHODS

The New York State Planning and Research Cooperative System (NY SPARCS) database was utilized to examine all adult patients who underwent fundoplication or PEH repair for the treatment of GERD between 2005 and 2010. The primary outcome was the incidence of each type of reoperation and the timing of the follow-up procedure/diagnosis of gastroparesis. Generalized linear mixed models were used to examine the risk factors for follow-up procedures/diagnosis.

RESULTS

A total of 5656 patients were analyzed, as 3512 (62.1%) patients underwent a primary fundoplication procedure and 2144 (37.9%) patients underwent a primary PEH repair. The majority of subsequent procedures (n = 254, 65.5%) were revisional procedures (revisional fundoplication or PEH repair) following a primary fundoplication. A total of 134 (3.8%) patients who underwent a primary fundoplication later had a diagnosis of gastroparesis or a follow-up procedure to treat gastroparesis, while 95 (4.4%) patients who underwent a primary PEH repair were later diagnosed with gastroparesis or underwent surgical treatment of gastroparesis.

CONCLUSION

The results revealed low reoperation rates following both fundoplication and PEH repairs, with no significant difference between the two groups. Additionally, PEH repair patients tended to be older and were more likely to have a comorbidity compared to fundoplication patients, particularly in the setting of hypertension, obesity, and fluid and electrolyte disorders. Further research is warranted to better understand these findings.

摘要

背景

关于胃食管反流病(GERD)患者行抗反流手术(如胃底折叠术或食管裂孔疝修补术)后再次手术或术后发生胃轻瘫(PSG)的自然病程,目前仅有少量大样本研究报道。对于 PSG 或复发的患者,再次行胃底折叠术或食管裂孔疝修补术,或行幽门成形术/幽门肌切开术,均是有效的治疗手段。本研究分析了在纽约州,胃底折叠术或食管裂孔疝修补术后发生 PSG 及需要行再次手术的发生率和相关危险因素。

方法

利用纽约州规划和研究合作系统(NY SPARCS)数据库,分析 2005 年至 2010 年间,因 GERD 行胃底折叠术或食管裂孔疝修补术的所有成年患者。主要结局为每种类型再次手术的发生率及 PSG 的随访诊断时间。采用广义线性混合模型分析随访诊断的危险因素。

结果

共分析了 5656 例患者,其中 3512 例(62.1%)患者行初次胃底折叠术,2144 例(37.9%)患者行初次食管裂孔疝修补术。大多数后续手术(n=254,65.5%)为初次胃底折叠术后的再次手术(再次胃底折叠术或食管裂孔疝修补术)。初次胃底折叠术后,共有 134 例(3.8%)患者诊断为胃轻瘫或行手术治疗胃轻瘫;初次食管裂孔疝修补术后,共有 95 例(4.4%)患者诊断为胃轻瘫或行手术治疗胃轻瘫。

结论

胃底折叠术和食管裂孔疝修补术后的再次手术率均较低,两组之间无显著差异。此外,与胃底折叠术患者相比,食管裂孔疝修补术患者年龄更大,且更易合并其他疾病,尤其是高血压、肥胖以及水、电解质紊乱。需要进一步研究以更好地理解这些发现。

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