Eckhardt R, Kloos P, Dierich M P, Meyer zum Büschenfelde K H
Gut. 1977 Dec;18(12):1010-6. doi: 10.1136/gut.18.12.1010.
Total lymphocyte counts, B-, T-, C'3 receptor-bearing lymphocytes, and K-cell activity were studied in peripheral blood in patients with Crohn's disease and inflammatory liver disease. Patients with active untreated Crohn's disease and acute virus B hepatitis exhibited a markedly increased K-cell activity measured in a plaque assay when compared with normal controls (P less than 0.01). Patients with immunosuppressive treated Crohn's disease, HBsAg-positive chronic active hepatitis, and cirrhosis of the liver showed only a slight increase of K-cell activity (P less than 0.01). In the postacute phase of hepatitis (four to 12 weeks from onset) K-cell activity fell to normal levels. The number of B-lymphocytes showed a relative and absolute decrease in all groups of patients. With the exception of patients with acute HBsAg-positive hepatitis and the post-acute phase of hepatitis all the other groups showed statistically decreased absolute numbers for C'3 receptor-bearing lymphocytes. The significant decrease in K-cell activity and the number of T-lymphocytes in Crohn's disease treated with immunosuppressive drugs was interpreted as an effect of azathioprine and prednisone on these lymphocyte subpopulations.
对克罗恩病和炎性肝病患者的外周血中的淋巴细胞总数、B淋巴细胞、T淋巴细胞、携带C'3受体的淋巴细胞以及K细胞活性进行了研究。与正常对照组相比，未经治疗的活动性克罗恩病患者和急性乙型病毒性肝炎患者在空斑试验中测得的K细胞活性显著增加（P<0.01）。接受免疫抑制治疗的克罗恩病患者、HBsAg阳性的慢性活动性肝炎患者和肝硬化患者的K细胞活性仅略有增加（P<0.01）。在肝炎的急性后期（发病后4至12周），K细胞活性降至正常水平。所有患者组中的B淋巴细胞数量均出现相对和绝对减少。除急性HBsAg阳性肝炎患者和肝炎急性后期患者外，所有其他组的携带C'3受体的淋巴细胞绝对数量在统计学上均减少。用免疫抑制药物治疗的克罗恩病患者的K细胞活性和T淋巴细胞数量显著减少，被解释为硫唑嘌呤和泼尼松对这些淋巴细胞亚群的作用。
