Sen Ashis Kumar, Raj Abhishek, Banerjee Utsab, Iqbal Sk Rameez
Department of Mechanical Engineering, Indian Institute of Technology Madras, Chennai, India.
Methods Mol Biol. 2019;1906:13-54. doi: 10.1007/978-1-4939-8964-5_2.
This chapter enumerates the methods, protocol, and safety procedures of various fabrication techniques for polymer-based microfluidic devices. The polymer materials can be a solid or a liquid, and the fabrication protocol needs to be executed accordingly. Various techniques demonstrating the fabrication of microfluidic devices using solid and liquid polymers are described. Procedure for each fabrication process is delineated with detailed images. Further, dos and don'ts for all the fabrication techniques are explained in the notes of each section. This chapter will benefit those interested in the microfluidic device fabrication using polymers and guide them to avoid mistakes so as to obtain an elegant device.The techniques are listed as follows: 1. Replica molding 2. Microcontact printing 3. Micro-transfer molding 4. Solvent-assisted molding 5. Hot embossing 6. Injection molding 7. CNC micromachining 8. Laser photo ablation 9. X-ray lithography 10. UV patterning 11. Plasma etching 12. Ion beam etching 13. Capillary molding 14. Micro-stereolithography.
本章列举了基于聚合物的微流控器件的各种制造技术的方法、流程和安全程序。聚合物材料可以是固体或液体，制造流程需要相应地执行。描述了使用固体和液体聚合物制造微流控器件的各种技术。每个制造过程的步骤都配有详细的图像进行描绘。此外，在每个部分的注释中都解释了所有制造技术的注意事项。本章将使那些对使用聚合物制造微流控器件感兴趣的人受益，并指导他们避免错误，从而获得一个精致的器件。这些技术如下：1. 复制成型 2. 微接触印刷 3. 微转移成型 4. 溶剂辅助成型 5. 热压花 6. 注塑成型 7. 计算机数控微加工 8. 激光光烧蚀 9. X射线光刻 10. 紫外线图案化 11. 等离子体蚀刻 12. 离子束蚀刻 13. 毛细管成型 14. 微立体光刻。
