Zhejiang University, State Key Lab of Modern Optical Instrumentation, Department of Optical Engineering, Institute of Advanced Nanophotonics, Zheda Road 38, Xihu District, Hangzhou, Zhejiang 310027, China.
J Biomed Opt. 2011 Aug;16(8):080901. doi: 10.1117/1.3607430.
Here we introduce the existing fabrication techniques, detection methods, and related techniques for microfluidic sensing, with an emphasis on the detection techniques. A general survey and comparison of the fabrication techniques were given, including prototyping (hot embossing, inject molding, and soft lithography) and direct fabrication (laser micromachining, photolithography, lithography, and x-ray lithography) techniques. This is followed by an in-depth look at detection techniques: optical, electrochemical, mass spectrometry, as well as nuclear magnetic resonance spectroscopy-based sensing approaches and related techniques. In the end, we highlight several of the most important issues for future work on microfluidic sensing. This article aims at providing a tutorial review with both introductory materials and inspiring information on microfluidic fabrication and sensing for nonspecialists.
在这里，我们介绍了现有的微流控传感制造技术、检测方法和相关技术，重点介绍了检测技术。我们对制造技术进行了全面的调查和比较，包括原型制作（热压印、注塑和软光刻）和直接制造（激光微加工、光刻、光刻和 X 射线光刻）技术。接下来，我们深入研究了检测技术：基于光学、电化学、质谱以及核磁共振光谱的传感方法和相关技术。最后，我们强调了微流控传感未来工作的几个最重要的问题。本文旨在为非专业人士提供关于微流控制造和传感的入门材料和启发性信息的教程综述。
