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短密青霉 E10 内生真菌中两个具有四环骨架的细胞松弛素 Curtachalasins A 和 B

Curtachalasins A and B, Two Cytochalasans with a Tetracyclic Skeleton from the Endophytic Fungus Xylaria curta E10.

机构信息

School of Pharmaceutical Sciences , South-Central University for Nationalities , Wuhan , Hubei 430074 , PR China.

出版信息

Org Lett. 2018 Dec 21;20(24):7758-7761. doi: 10.1021/acs.orglett.8b03110. Epub 2018 Nov 30.

DOI:10.1021/acs.orglett.8b03110
PMID:30499682
Abstract

Two unique cytochalasans, curtachalasins A (1) and B (2), were purified from the endophytic fungus Xylaria curta E10 harbored in the plant Solanum tuberosum. Their structures were determined by extensive spectroscopic methods, X-ray crystallographic analysis, and electronic circular dichroism calculations. These two compounds feature an unprecedented pyrolidine/perhydroanthracene (5/6/6/6 tetracyclic skeleton) fused ring system.

摘要

从寄生于植物马铃薯（Solanum tuberosum）的内生真菌卷毛壳菌（Xylaria curta）E10 中分离得到两种独特的细胞松弛素，分别命名为 curtachalasin A（1）和 curtachalasin B（2）。通过广泛的光谱方法、X 射线晶体学分析和电子圆二色性计算确定了它们的结构。这两种化合物具有前所未有的吡咯烷/全氢蒽（5/6/6/6 四环骨架）稠合环系统。

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