用针对IgM或IgD的抗血清阻断对非胸腺依赖性和胸腺依赖性抗原的体外初次抗体反应。
Blocking of primary in vitro antibody responses to thymus-independent and thymus-dependent antigens with antiserum specific for IgM or IgD.
作者信息
Cambier J C, Ligler F S, Uhr J W, Kettman J R, Vitetta E S
出版信息
Proc Natl Acad Sci U S A. 1978 Jan;75(1):432-5. doi: 10.1073/pnas.75.1.432.
Abstract
The effect of anti-mu and anti-delta on the primary in vitro IgM response of murine splenocytes to thymus-dependent (trinitrophenylated erythrocytes) and thymus-independent (trinitrophenylated brucella) forms of trinitrophenyl was studied. The results indicate that either anti-mu or anti-delta can block the response of adult splenocytes to the thymus-dependent antigen. The thymus-dependent responses of neonatal splenocytes that bear a low concentration of IgD were also abrogated by treatment with anti-delta. In contrast, anti-mu, but not anti-delta, blocked the response of adult splenocytes to the thymus-independent antigen used. These results indicate that both IgM and IgD are receptors required for triggering cells by a thymus-dependent antigen but that only IgM receptors are required for triggering by the thymus-independent antigen used.
摘要
研究了抗μ和抗δ对小鼠脾细胞体外对胸腺依赖性（三硝基苯基化红细胞）和胸腺非依赖性（三硝基苯基化布鲁氏菌）形式的三硝基苯基的初次IgM反应的影响。结果表明，抗μ或抗δ均可阻断成年脾细胞对胸腺依赖性抗原的反应。用抗δ处理也可消除低浓度IgD的新生脾细胞的胸腺依赖性反应。相反，抗μ而非抗δ阻断了成年脾细胞对所用胸腺非依赖性抗原的反应。这些结果表明，IgM和IgD都是胸腺依赖性抗原触发细胞所需的受体，但所用胸腺非依赖性抗原触发细胞仅需IgM受体。
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