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1
Blocking of primary in vitro antibody responses to thymus-independent and thymus-dependent antigens with antiserum specific for IgM or IgD.用针对IgM或IgD的抗血清阻断对非胸腺依赖性和胸腺依赖性抗原的体外初次抗体反应。
Proc Natl Acad Sci U S A. 1978 Jan;75(1):432-5. doi: 10.1073/pnas.75.1.432.
2
A dichotomy between the expression of IgD on B cells and its requirement for triggering such cells with two T-independent antigens.B细胞上IgD的表达与其用两种非T细胞依赖性抗原触发此类细胞的需求之间的二分法。
J Exp Med. 1979 Apr 1;149(4):987-92. doi: 10.1084/jem.149.4.987.
3
B-cell tolerance. IV. Differential role of surface IgM and IgD in determining tolerance susceptibility of murine B cells.B细胞耐受性。IV. 表面IgM和IgD在决定小鼠B细胞耐受性易感性中的不同作用。
J Exp Med. 1977 Dec 1;146(6):1804-8. doi: 10.1084/jem.146.6.1804.
4
The murine B cell response to TNP-polyacrylamide beads: the relationship between the epitope density of the antigen and the requirements for T cell help and surface IgD.小鼠B细胞对三硝基苯-聚丙烯酰胺珠的反应：抗原表位密度与T细胞辅助及表面IgD需求之间的关系
J Immunol. 1980 Jul;125(1):420-7.
5
Inactivation of antigen-responsive clones with antisera specific for IgM or IgD.用针对IgM或IgD的抗血清使抗原反应性克隆失活。
J Immunol. 1978 Apr;120(4):1139-42.
6
The class of surface immunoglobulin on virgin and memory B lymphocytes.处女型和记忆性B淋巴细胞表面免疫球蛋白的类别。
J Immunol. 1977 May;118(5):1806-15.
7
Antigen-induced co-capping of IgM and IgD-like receptors on murine B cells.抗原诱导小鼠B细胞上IgM和IgD样受体的共帽化。
J Exp Med. 1976 Sep 1;144(3):852-7. doi: 10.1084/jem.144.3.852.
8
Augmentation of in vitro humoral immune responses in the mouse by an antibody to IgD.抗IgD抗体增强小鼠体外体液免疫反应。
J Exp Med. 1980 Sep 1;152(3):493-506. doi: 10.1084/jem.152.3.493.
9
Effects of neonatal anti-delta antibody treatment on the murine immune system. I. Suppression of development of surface IgD+ B cells and expansion of a surface IgM+ IgD- B lymphocyte population.新生鼠抗δ抗体治疗对小鼠免疫系统的影响。I. 表面IgD+B细胞发育的抑制及表面IgM+IgD-B淋巴细胞群体的扩增。
J Immunol. 1983 Aug;131(2):593-600.
10
Role of IgD in the immune response and tolerance. II. Precursor analysis of murine B cells separated on the basis of surface IgD or treated with an anti-delta serum.IgD在免疫应答和免疫耐受中的作用。II. 基于表面IgD分离或用抗δ血清处理的小鼠B细胞的前体分析。
Eur J Immunol. 1978 Jan;8(1):13-6. doi: 10.1002/eji.1830080104.

引用本文的文献

1
Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells.免疫球蛋白D（IgD）缺陷小鼠揭示了IgD在抗原介导的B细胞募集中的辅助受体功能。
J Exp Med. 1993 Jan 1;177(1):45-55. doi: 10.1084/jem.177.1.45.
2
The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein.B淋巴细胞的IgM抗原受体与抑制素及一种抑制素相关蛋白相关联。
EMBO J. 1994 Aug 15;13(16):3782-92. doi: 10.1002/j.1460-2075.1994.tb06689.x.
3
Physiology of IgD. I. Compensatory phenomena in B lymphocyte activation in mice treated with anti-IgD antibodies.IgD的生理学。I. 用抗IgD抗体处理的小鼠B淋巴细胞激活中的代偿现象。
J Exp Med. 1981 Aug 1;154(2):318-32. doi: 10.1084/jem.154.2.318.
4
Augmentation of in vitro humoral immune responses in the mouse by an antibody to IgD.抗IgD抗体增强小鼠体外体液免疫反应。
J Exp Med. 1980 Sep 1;152(3):493-506. doi: 10.1084/jem.152.3.493.
5
Ontogenic development of B-lymphocyte function and tolerance susceptibility in vivo and in an in vitro organ culture system.体内及体外器官培养系统中B淋巴细胞功能的个体发生发展及耐受易感性
J Exp Med. 1980 Feb 1;151(2):429-45. doi: 10.1084/jem.151.2.429.
6
Regulation of murine B cells through surface immunoglobulin. I. Monoclonal anti-delta antibody that induces allotype-specific proliferation.通过表面免疫球蛋白对小鼠B细胞的调节。I. 诱导同种异型特异性增殖的单克隆抗δ抗体。
J Exp Med. 1980 Nov 1;152(5):1135-46. doi: 10.1084/jem.152.5.1135.
7
Specific T helper cells that activate B cells polyclonally. In vitro enrichment and cooperative function.可多克隆激活B细胞的特异性辅助性T细胞。体外富集及协同功能。
J Exp Med. 1980 Mar 1;151(3):587-601. doi: 10.1084/jem.151.3.587.
8
The expression of surface IgD on B cells responsive to thymus-independent and thymus-dependent antigens and its requirement for B-cell triggering.对非胸腺依赖性抗原和胸腺依赖性抗原产生反应的B细胞表面IgD的表达及其对B细胞触发的需求。
Immunology. 1983 Feb;48(2):393-400.
9
Definition of conditions that enable antigen-specific activation of the majority of isolated trinitrophenol-binding B cells.能够使大多数分离出的三硝基苯酚结合B细胞发生抗原特异性激活的条件的定义。
J Exp Med. 1982 Dec 1;156(6):1635-49. doi: 10.1084/jem.156.6.1635.
10
Assessment of antigen-specific receptor function of surface immunoglobulin M and D with identical hapten specificity.具有相同半抗原特异性的表面免疫球蛋白M和D的抗原特异性受体功能评估。
Proc Natl Acad Sci U S A. 1987 Jun;84(11):3831-5. doi: 10.1073/pnas.84.11.3831.

本文引用的文献

1
Cell populations and cell proliferation in the in vitro response of normal mouse spleen to heterologous erythrocytes. Analysis by the hot pulse technique.正常小鼠脾脏对异种红细胞体外反应中的细胞群体与细胞增殖。热脉冲技术分析
J Exp Med. 1967 Sep 1;126(3):443-54. doi: 10.1084/jem.126.3.443.
2
Immunization of normal mouse spleen cell suspensions in vitro.体外对正常小鼠脾细胞悬液进行免疫接种。
Science. 1966 Aug 26;153(3739):1004-6. doi: 10.1126/science.153.3739.1004.
3
Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.抗三硝基苯基（TNP）空斑试验。Balb/c小鼠对可溶性和颗粒性免疫原的初次反应。
Proc Soc Exp Biol Med. 1969 Nov;132(2):575-81. doi: 10.3181/00379727-132-34264.
4
An in vitro primary immune response to 2,4,6-trinitrophenyl substituted erythrocytes: response against carrier and hapten.对2,4,6-三硝基苯基取代红细胞的体外初次免疫反应：针对载体和半抗原的反应。
J Immunol. 1970 Jun;104(6):1558-61.
5
Differential stimulation of precursor cells and carrier-specific thymus-derived cell activity in the in vivo reponse to heterologous erythrocytes in mice.小鼠体内对异种红细胞反应中前体细胞的差异刺激及载体特异性胸腺来源细胞活性
J Immunol. 1972 Jan;108(1):54-8.
6
Enumeration and analysis of antibody-forming cell precursors in the neonatal mouse.新生小鼠中抗体形成细胞前体的计数与分析
J Immunol. 1973 Sep;111(3):829-35.
7
Synthesis, surface deposition and secretion of immunoglobulin M in bone marrow-derived lymphocytes before and after mitogenic stimulation.有丝分裂原刺激前后骨髓来源淋巴细胞中免疫球蛋白M的合成、表面沉积及分泌
Transplant Rev. 1973;14:76-130. doi: 10.1111/j.1600-065x.1973.tb00103.x.
8
Immune responses in vitro. V. Suppression of M, G, and A plaque-forming cell responses in cultures of primed mouse spleen cells by class-specific antibody to mouse immunoglobulins.体外免疫反应。V. 用小鼠免疫球蛋白类特异性抗体对致敏小鼠脾细胞培养物中M、G和A斑块形成细胞反应的抑制作用。
J Exp Med. 1972 Mar 1;135(3):698-710. doi: 10.1084/jem.135.3.698.
9
Immune responses in vitro. IV. Suppression of primary M, G, and A plaque-forming cell responses in mouse spleen cell cultures by class-specific antibody to mouse immunoglobulins.体外免疫反应。IV. 用小鼠免疫球蛋白的类特异性抗体抑制小鼠脾细胞培养物中初级M、G和A斑块形成细胞反应。
J Exp Med. 1972 Mar 1;135(3):675-97. doi: 10.1084/jem.135.3.675.
10
Candidate for immunoglobulin D present on murine B lymphocytes.鼠B淋巴细胞上免疫球蛋白D的候选物。
Nature. 1974 Dec 13;252(5484):600-2. doi: 10.1038/252600a0.

用针对IgM或IgD的抗血清阻断对非胸腺依赖性和胸腺依赖性抗原的体外初次抗体反应。

Blocking of primary in vitro antibody responses to thymus-independent and thymus-dependent antigens with antiserum specific for IgM or IgD.

作者信息

Cambier J C, Ligler F S, Uhr J W, Kettman J R, Vitetta E S

出版信息

Proc Natl Acad Sci U S A. 1978 Jan;75(1):432-5. doi: 10.1073/pnas.75.1.432.

DOI:10.1073/pnas.75.1.432
PMID:305047
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC411263/
Abstract

The effect of anti-mu and anti-delta on the primary in vitro IgM response of murine splenocytes to thymus-dependent (trinitrophenylated erythrocytes) and thymus-independent (trinitrophenylated brucella) forms of trinitrophenyl was studied. The results indicate that either anti-mu or anti-delta can block the response of adult splenocytes to the thymus-dependent antigen. The thymus-dependent responses of neonatal splenocytes that bear a low concentration of IgD were also abrogated by treatment with anti-delta. In contrast, anti-mu, but not anti-delta, blocked the response of adult splenocytes to the thymus-independent antigen used. These results indicate that both IgM and IgD are receptors required for triggering cells by a thymus-dependent antigen but that only IgM receptors are required for triggering by the thymus-independent antigen used.

摘要

研究了抗μ和抗δ对小鼠脾细胞体外对胸腺依赖性（三硝基苯基化红细胞）和胸腺非依赖性（三硝基苯基化布鲁氏菌）形式的三硝基苯基的初次IgM反应的影响。结果表明，抗μ或抗δ均可阻断成年脾细胞对胸腺依赖性抗原的反应。用抗δ处理也可消除低浓度IgD的新生脾细胞的胸腺依赖性反应。相反，抗μ而非抗δ阻断了成年脾细胞对所用胸腺非依赖性抗原的反应。这些结果表明，IgM和IgD都是胸腺依赖性抗原触发细胞所需的受体，但所用胸腺非依赖性抗原触发细胞仅需IgM受体。