Center for Reproductive Medicine, Drum Tower Clinic Medical College of Nanjing Medical University, Nanjing 210029, Jiangsu, China.
MRC Center for Regenerative Medicine, University of Edinburgh, Edinburgh, EH16 4UU, United Kingdom.
Curr Stem Cell Res Ther. 2019;14(4):293-304. doi: 10.2174/1574888X14666181205120110.
Monthly changes in the endometrial cycle indicate the presence of endometrial stem cells. In recent years, various stem cells that exist in the endometrium have been identified and characterized. Additionally, many studies have shown that Bone Marrow Mesenchymal Stem Cells (BM-MSCs) provide an alternative source for regenerating the endometrium and repairing endometrial injury. This review discusses the origin of endometrial stem cells, the characteristics and main biomarkers among five types of putative endometrial stem cells, applications of endometrium-derived stem cells and menstrual blood-derived stem cells, the association between BM-MSCs and endometrial stem cells, and progress in repairing endometrial injury.
子宫内膜周期的每月变化表明存在子宫内膜干细胞。近年来，已鉴定和表征了存在于子宫内膜中的各种干细胞。此外，许多研究表明骨髓间充质干细胞（BM-MSCs）为子宫内膜再生和修复子宫内膜损伤提供了替代来源。本综述讨论了子宫内膜干细胞的起源，五种假定的子宫内膜干细胞的特征和主要生物标志物，子宫内膜来源的干细胞和月经血来源的干细胞的应用，BM-MSCs 和子宫内膜干细胞之间的关联，以及修复子宫内膜损伤的进展。
