Pediatric Center of Excellence, Indira Gandhi Institute of Child Health, Dharmaram College Post, South Hospital Complex, Bangalore 560 029, Karnataka, India.
Asha Kirana Hospital, Hebbal Industrial Housing Area, Ring Road, Hebbal, Mysore 570016, Karnataka, India.
Indian J Pediatr. 2019 Mar;86(3):233-240. doi: 10.1007/s12098-018-2816-8. Epub 2018 Dec 13.
In India, access to free anti-retroviral therapy has improved the survival of perinatally human immunodeficiency virus (HIV) infected children resulting in the transition of many such children to adulthood. This study aims to understand the social-outcomes and quality of life (QOL) among these adults.
This cross-sectional study was conducted in two tertiary HIV care centers in south India. Perinatally HIV-infected adults aged >18 y were enrolled after obtaining consent. Data were collected by questionnaire based interviews for social outcomes and WHO Quality of Life-BREF (WHOQOL-BREF) for QOL. The social-outcome indicators monitored pertained to family support, educational qualification and occupational, economic, and marital status.
The mean age of 107 participants was 18·9 ± 1·1y. The school drop-out rate was 58%. Sixty-two percent were double orphans. Forty-three-percent of the participants were employed with mean per-capita monthly income of Rs.4105 ± 2979 ($65·2 ± 47·3). Fourteen-percent of the participants were married, or in a relationship, and a majority of them, 93%, were females. For QOL, the mean raw score was highest for social relationship (15·79). Relative to studying subjects, a higher proportion of school dropouts scored poorly in social relationship (42% vs.14·8%; Chi-square = 5·28; p = 0·02) and environmental QOL (46% vs.19·6%;Chi-square = 8·09; p = 0·004). The proportion of subjects with a poor physical health QOL was higher among those with a per-capita monthly income above the national average than those with below the national average (69% vs.33·3%; Chi-square = 5·27; p = 0·02).
Though clinico-immunological disease was stable in these perinatally HIV-infected young adults, their social-outcomes pertaining to education, occupation, income, and family support were poor. Factors like education, parental care, and income of the subjects were associated with poor QOL.
在印度，获得免费抗逆转录病毒治疗改善了围产期感染人类免疫缺陷病毒（HIV）的儿童的生存状况，导致许多此类儿童进入成年期。本研究旨在了解这些成年人的社会结局和生活质量（QOL）。
本横断面研究在印度南部的两个三级艾滋病毒护理中心进行。在获得同意后，招募了年龄大于 18 岁的围产期 HIV 感染成年人。通过问卷进行社会结果调查，采用世界卫生组织生活质量简表（WHOQOL-BREF）进行 QOL 调查。监测的社会结局指标包括家庭支持、教育程度以及职业、经济和婚姻状况。
107 名参与者的平均年龄为 18.9±1.1 岁。辍学率为 58%。62%是双重孤儿。43%的参与者有工作，人均月收入为 4105±2979 卢比（65.2±47.3 美元）。14%的参与者已婚或处于恋爱关系中，其中大多数为女性，占 93%。在 QOL 方面，社会关系的原始得分最高，平均为 15.79。与在校学习的受试者相比，辍学的受试者在社会关系（42%比 14.8%；卡方=5.28；p=0.02）和环境 QOL（46%比 19.6%；卡方=8.09；p=0.004）方面的评分较差。人均月收入高于全国平均水平的受试者中，身体 QOL 较差的比例高于收入低于全国平均水平的受试者（69%比 33.3%；卡方=5.27；p=0.02）。
尽管这些围产期 HIV 感染的年轻成年人的临床免疫疾病稳定，但他们在教育、职业、收入和家庭支持方面的社会结局较差。受试者的教育、父母照顾和收入等因素与较差的 QOL 相关。
