State Key Laboratory of Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University, Nanchang, 330045, China.
College of Bioscience and Engineering, Jiangxi Agricultural University, Nanchang, China.
BMC Microbiol. 2018 Dec 14;18(1):215. doi: 10.1186/s12866-018-1364-8.
There are growing evidences showing that gut microbiota should play an important role in host appetite and feeding behavior. However, what kind of microbe(s) and how they affect porcine appetite remain unknown.
In this study, 280 commercial Duroc pigs were raised in a testing station with the circadian feeding behavior records for a continuous period of 30-100 kg. We first analyzed the influences of host gender and genetics in porcine average daily feed intake (ADFI), but no significant effect was observed. We found that the Prevotella-predominant enterotype had a higher ADFI than the Treponema enterotype-like group. Furthermore, 12 out of the 18 OTUs positively associated with the ADFI were annotated to Prevotella, and Prevotella was the hub bacteria in the co-abundance network. These results suggested that Prevotella might be a keystone bacterial taxon for increasing host feed intake. However, some bacteria producing short-chain fatty acids (SCFAs) and lactic acid (e.g. Ruminococcaceae and Lactobacillus) showed negative associations with the ADFI. Predicted function capacity analysis showed that the genes for amino acid biosynthesis had significantly different enrichment between pigs with high and low ADFI.
The present study provided important information on the profound effect of gut microbiota on porcine appetite and feeding behavior. This will profit us to regulate porcine appetite through modulating the gut microbiome in the pig industry.
越来越多的证据表明，肠道微生物群应该在宿主的食欲和进食行为中发挥重要作用。然而，什么样的微生物（s）以及它们如何影响猪的食欲仍然未知。
本研究中，280 头商业杜洛克猪在一个测试站饲养，记录了连续 30-100kg 期间的昼夜摄食行为。我们首先分析了宿主性别和遗传对猪平均日采食量（ADFI）的影响，但没有观察到显著影响。我们发现，拟杆菌型肠型的 ADFI 高于似螺旋体肠型组。此外，与 ADFI 呈正相关的 18 个 OTU 中有 12 个被注释为拟杆菌，拟杆菌是共丰度网络中的枢纽细菌。这些结果表明，拟杆菌可能是增加宿主采食量的关键细菌分类群。然而，一些产生短链脂肪酸（SCFAs）和乳酸的细菌（如瘤胃球菌科和乳杆菌）与 ADFI 呈负相关。预测功能能力分析表明，高 ADFI 和低 ADFI 猪之间的氨基酸生物合成基因具有显著不同的富集。
本研究提供了关于肠道微生物群对猪食欲和进食行为的深远影响的重要信息。这将使我们能够通过调节猪的肠道微生物群来调节猪的食欲。
