Sköldenberg B, Stiernstedt G, Karlsson M, Wretlind B, Svenungsson B
Department of Infectious Diseases, Danderyd Hospital, Sweden.
Ann N Y Acad Sci. 1988;539:317-23. doi: 10.1111/j.1749-6632.1988.tb31866.x.
We have studied 113 patients with neurologic Lyme borreliosis and meningitis who were treated with intravenous high-dose antibiotics (penicillin G, 12 g, mostly for 14 days in 47 patients; penicillin G, 9 g, mostly for 10 days in 58 patients; doxycycline, 200 mg, in 5 patients; and cefuroxime, 4.5-9 g, in 3 patients). Seventy percent of the patients had peripheral nerve symptoms and 13% had central nervous symptoms. Almost half of the patients were treated more than 4 weeks after the onset of symptoms and 15% of the patients had persisting or progressive symptoms between 4 and 11 months. There seemed to be clinical benefit as well as a decrease of spinal fluid pleocytosis and spinal proteins. No significant symptoms of Herxheimer reaction were demonstrated.
我们研究了113例患有神经型莱姆病和脑膜炎的患者，他们接受了静脉注射大剂量抗生素治疗（47例患者使用青霉素G，12克，大多为14天；58例患者使用青霉素G，9克，大多为10天；5例患者使用强力霉素，200毫克；3例患者使用头孢呋辛，4.5 - 9克）。70%的患者有周围神经症状，13%有中枢神经症状。几乎一半的患者在症状出现4周后才接受治疗，15%的患者在4至11个月之间有持续或进展性症状。似乎有临床获益，同时脑脊液细胞增多和脊髓蛋白也有所减少。未出现赫克斯海默反应的明显症状。
