Karlsson M, Hammers-Berggren S, Lindquist L, Stiernstedt G, Svenungsson B
Karolinska Institute, Stockholm, Sweden.
Neurology. 1994 Jul;44(7):1203-7. doi: 10.1212/wnl.44.7.1203.
To compare the efficacy of oral doxycycline and IV penicillin G for the treatment of neuroborreliosis, we randomized consecutive patients with Lyme neuroborreliosis to receive either IV penicillin G (3 g q 6 h) or oral deoxycycline (200 mg q 24 h) for 14 days. All patients had antibodies against Borrelia burgdorferi in serum, CSF, or both, or had a positive CSF culture. Twenty-three patients randomized to penicillin G and 31 patients to doxycycline were included in the study. All patients improved during treatment, and there were no significant differences between the two treatment groups in patient scoring, CSF analysis, or serologic and clinical follow-up during 1 year. There were no treatment failures, although one patient in each treatment group was re-treated because of residual symptoms. In conclusion, oral doxycycline is an adequate and cost-effective alternative to IV penicillin for the treatment of Lyme neuroborreliosis.
为比较口服强力霉素和静脉注射青霉素G治疗神经型莱姆病的疗效，我们将连续的莱姆神经型疏螺旋体病患者随机分组，分别接受静脉注射青霉素G（3克，每6小时一次）或口服多西环素（200毫克，每天一次）治疗14天。所有患者血清、脑脊液或两者中均有抗伯氏疏螺旋体抗体，或脑脊液培养呈阳性。23例随机接受青霉素G治疗的患者和31例接受多西环素治疗的患者纳入研究。所有患者在治疗期间均有改善，两个治疗组在患者评分、脑脊液分析或1年期间的血清学及临床随访方面均无显著差异。虽然每个治疗组各有1例患者因残留症状接受了再次治疗，但均未出现治疗失败的情况。总之，口服多西环素是治疗莱姆神经型疏螺旋体病的一种适当且具有成本效益的替代静脉注射青霉素的药物。
