Lee Jae-Ho, Ahn Soo-Yeon, Lee Hyon Ah, Won Kyoung Sook, Chang Hyuk Won, Oh Jungsu S, Kim Hae Won
Department of Anatomy, Keimyung University Dongsan Medical Center, Daegu, Republic of Korea.
Department of Neurology, Keimyung University Dongsan Medical Center, Daegu, Republic of Korea.
Food Nutr Res. 2018 Dec 10;62. doi: 10.29219/fnr.v62.1415. eCollection 2018.
Alzheimer's disease (AD) is a neurodegenerative disease characterized by the deposition of amyloid-β peptide (Aβ) in diffuse and neuritic plaques. Previous research has suggested that certain vitamins may prevent this process. In the present study, we evaluated the relationship between vitamin intake and cerebral Aβ burden in patients with cognitive impairment. This study included 19 patients with subjective cognitive impairment and 30 patients with mild cognitive impairment. All patients underwent brain MRI and F-florbetaben positron emission tomography. The Food Frequency Questionnaire was used to evaluate dietary intake of the 15 vitamins. Intake of vitamin B6 ( = 0.027), vitamin K ( = 0.042), vitamin A ( = 0.063), riboflavin ( = 0.063), β-carotene ( = 0.081), pantothenic acid ( = 0.092), and niacin ( = 0.097) was higher in the Aβ-positive group than in the Aβ-negative group. Multivariate linear regression analysis revealed that pantothenic acid intake was an independent determinant of cerebral Aβ burden (β = 0.287, = 0.029). No significant correlations were observed between cerebral Aβ burden and the intake of other vitamins. Our findings demonstrated that pantothenic acid intake may be associated with increased cerebral Aβ burden in patients with cognitive impairment. These results may offer insight into potential strategies for AD prevention.
阿尔茨海默病（AD）是一种神经退行性疾病，其特征在于淀粉样β肽（Aβ）在弥漫性和神经炎斑块中的沉积。先前的研究表明，某些维生素可能会阻止这一过程。在本研究中，我们评估了认知障碍患者维生素摄入量与脑Aβ负荷之间的关系。本研究纳入了19例主观认知障碍患者和30例轻度认知障碍患者。所有患者均接受了脑部MRI和F-氟代苯并噻唑正电子发射断层扫描。食物频率问卷用于评估15种维生素的饮食摄入量。Aβ阳性组中维生素B6（=0.027）、维生素K（=0.042）、维生素A（=0.063）、核黄素（=0.063）、β-胡萝卜素（=0.081）、泛酸（=0.092）和烟酸（=0.097）的摄入量高于Aβ阴性组。多变量线性回归分析显示，泛酸摄入量是脑Aβ负荷的独立决定因素（β=0.287，=0.029）。未观察到脑Aβ负荷与其他维生素摄入量之间存在显著相关性。我们的研究结果表明，泛酸摄入量可能与认知障碍患者脑Aβ负荷增加有关。这些结果可能为AD预防的潜在策略提供见解。
