阿尔茨海默病中的神经炎症：异质性来源及个性化治疗靶点
Neuroinflammation in Alzheimer's disease; A source of heterogeneity and target for personalized therapy.
作者信息
Latta C H, Brothers H M, Wilcock D M
机构信息
University of Kentucky, Sanders-Brown Center on Aging, Department of Physiology, Lexington, KY 40536, USA; The University of Manchester, Department of Biology, Manchester M13 9PL, United Kingdom.
University of Kentucky, Sanders-Brown Center on Aging, Department of Physiology, Lexington, KY 40536, USA.
出版信息
Neuroscience. 2015 Aug 27;302:103-11. doi: 10.1016/j.neuroscience.2014.09.061. Epub 2014 Oct 5.
Neuroinflammation has long been known as an accompanying pathology of Alzheimer's disease. Microglia surrounding amyloid plaques in the brain of Auguste D were described in the original publication of Alois Alzheimer. It is only quite recently, however, that we have a more complete appreciation for the diverse roles of neuroinflammation in neurodegenerative disorders such as Alzheimer's. While gaps in our knowledge remain, and conflicting data are abound in the field, our understanding of the complexities and heterogeneous functions of the inflammatory response in Alzheimer's is vastly improved. This review article will discuss some of the roles of neuroinflammation in Alzheimer's disease, in particular, how understanding heterogeneity in the individual inflammatory response can be used in therapeutic development and as a mechanism of personalizing our treatment of the disease.
神经炎症长期以来一直被认为是阿尔茨海默病的伴随病理特征。阿洛伊斯·阿尔茨海默的原始出版物中描述了奥古斯特·D大脑中围绕淀粉样斑块的小胶质细胞。然而，直到最近，我们才更全面地认识到神经炎症在诸如阿尔茨海默病等神经退行性疾病中的多种作用。尽管我们的知识仍存在空白，且该领域存在大量相互矛盾的数据，但我们对阿尔茨海默病中炎症反应的复杂性和异质性功能的理解有了极大的提高。这篇综述文章将讨论神经炎症在阿尔茨海默病中的一些作用，特别是，了解个体炎症反应中的异质性如何能够用于治疗开发，并作为我们对该疾病进行个性化治疗的一种机制。
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