Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
Department of Palliative Medicine, Bispebjerg Hospital, Copenhagen, Denmark.
Eur J Cancer. 2019 Jan;107:133-141. doi: 10.1016/j.ejca.2018.11.023. Epub 2018 Dec 18.
The computer-adaptive test (CAT) of the European Organisation for Research and Treatment of Cancer (EORTC), the EORTC CAT Core, assesses the same 15 domains as the EORTC QLQ-C30 health-related quality of life questionnaire but with increased precision, efficiency, measurement range and flexibility. CAT parameters for estimating scores have been established based on clinical data from cancer patients. This study aimed at establishing the European Norm for each CAT domain based on general population data.
We collected representative general population data across 11 European Union (EU) countries, Russia, Turkey, Canada and the United States (n ≥ 1000/country; stratified by sex and age). We selected item subsets from each CAT domain for data collection (totalling 86 items). Differential item functioning (DIF) analyses were conducted to investigate cross-cultural measurement invariance. For each domain, means and standard deviations from the EU countries (weighted by country population, sex and age) were used to establish a T-metric with a European general population mean = 50 (standard deviation = 10).
A total of 15,386 respondents completed the online survey (n = 11,343 from EU countries). EORTC CAT Core norm scores for all 15 countries were calculated. DIF had negligible impact on scoring. Domain-specific T-scores differed significantly across countries with small to medium effect sizes.
This study establishes the official European Norm for the EORTC CAT Core. The European CAT Norm can be used globally and allows for meaningful interpretation of scores. Furthermore, CAT scores can be compared with sex- and age-adjusted norm scores at a national level within each of the 15 countries.
欧洲癌症研究与治疗组织（EORTC）的计算机自适应测试（CAT），即 EORTC CAT 核心，评估了与 EORTC QLQ-C30 健康相关生活质量问卷相同的 15 个领域，但具有更高的精度、效率、测量范围和灵活性。基于癌症患者的临床数据，已经建立了用于估计分数的 CAT 参数。本研究旨在基于一般人群数据为每个 CAT 领域建立欧洲标准。
我们在 11 个欧盟国家、俄罗斯、土耳其、加拿大和美国收集了具有代表性的一般人群数据（每个国家/地区 n≥1000；按性别和年龄分层）。我们从每个 CAT 领域中选择了项目子集进行数据收集（共 86 项）。进行了差异项目功能（DIF）分析，以调查跨文化测量不变性。对于每个领域，使用欧盟国家（按国家人口、性别和年龄加权）的数据来建立 T 度量标准，其中欧洲一般人群的平均值为 50（标准差为 10）。
共有 15386 名受访者完成了在线调查（来自欧盟国家的 n=11343）。计算了 15 个国家的 EORTC CAT 核心标准分数。DIF 对评分的影响可以忽略不计。特定于域的 T 分数在国家之间存在显著差异，具有小到中等的效应大小。
本研究建立了 EORTC CAT 核心的官方欧洲标准。欧洲 CAT 标准可在全球范围内使用，并允许对分数进行有意义的解释。此外，CAT 分数可以在每个国家的国家一级与按性别和年龄调整的标准分数进行比较。
