Legnaro National Laboratories, Italian National Institute for Nuclear Physics (LNL-INFN), Viale dell'Università, 2, 35020 Legnaro (PD), Italy.
Department of Physic and Earth Science, University of Ferrara, Via Saragat, 1, 44122 Ferrara, Italy.
Molecules. 2018 Dec 21;24(1):20. doi: 10.3390/molecules24010020.
The widespread availability of novel radioactive isotopes showing nuclear characteristics suitable for diagnostic and therapeutic applications in nuclear medicine (NM) has experienced a great development in the last years, particularly as a result of key advancements of cyclotron-based radioisotope production technologies. At Legnaro National Laboratories of the National Institute of Nuclear Physics (LNL-INFN), Italy, a 70-MeV high current cyclotron has been recently installed. This cyclotron will be dedicated not only to pursuing fundamental nuclear physics studies, but also to research related to other scientific fields with an emphasis on medical applications. LARAMED project was established a few years ago at LNL-INFN as a new research line aimed at exploiting the scientific power of nuclear physics for developing innovative applications to medicine. The goal of this program is to elect LNL as a worldwide recognized hub for the development of production methods of novel medical radionuclides, still unavailable for the scientific and clinical community. Although the research facility is yet to become fully operative, the LARAMED team has already started working on the cyclotron production of conventional medical radionuclides, such as Tc-99m, and on emerging radionuclides of high potential medical interest, such as Cu-67, Sc-47, and Mn-52.
近年来,新型放射性同位素的广泛应用为核医学(NM)的诊断和治疗应用提供了具有核特性的合适选择,这方面取得了重大进展,特别是得益于基于回旋加速器的放射性同位素生产技术的关键进步。在意大利国家核物理研究所(LNL-INFN)的莱尼亚诺国家实验室,最近安装了一台 70 MeV 强流回旋加速器。该回旋加速器不仅将专门用于开展基础核物理研究,还将重点关注其他科学领域的研究,特别是医学应用。几年前,LNL-INFN 成立了 LARAMED 项目,作为一条新的研究路线,旨在利用核物理的科学力量为医学开发创新应用。该计划的目标是使 LNL 成为全球公认的生产新型医用放射性核素的中心,这些放射性核素目前尚未可供科学界和临床界使用。尽管研究设施尚未全面投入运行,但 LARAMED 团队已经开始研究回旋加速器生产常规医用放射性核素,如 Tc-99m,以及具有高潜在医学应用价值的新兴放射性核素,如 Cu-67、Sc-47 和 Mn-52。