Department of Translational Medicine, University of Ferrara, Via Fossato di Mortara, 70 c/o viale Eliporto, 44121 Ferrara, Italy.
Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via L. Borsari, 46, 44121 Ferrara, Italy.
Molecules. 2021 Sep 21;26(18):5699. doi: 10.3390/molecules26185699.
The trend to achieve even more compact-sized systems is leading to the development of micro-scale reactors (lab-on-chip) in the field of radiochemical separation and radiopharmaceutical production. Technetium-99m extraction from both high and low specific activity molybdenum could be simply performed by MEK-driven solvent extraction if it were not for unpractical automation. The aim of this work is to develop a solvent extraction and separation process of technetium from molybdenum in a micro-scale in-flow chemistry regime with the aid of a capillary loop and a membrane-based separator, respectively. The developed system is able to extract and separate quantitatively and selectively (91.0 ± 1.8% decay corrected) the [Tc]TcONa in about 20 min, by using a ZAIPUT separator device. In conclusion, we demonstrated for the first time in our knowledge the high efficiency of a MEK-based solvent extraction process of Tc from a molybdenum-based liquid phased in an in-flow micro-scale regime.
实现更紧凑尺寸系统的趋势正在引领放射性化学分离和放射性药物生产领域的微尺度反应器（芯片实验室）的发展。如果不是因为不切实际的自动化，高和低比活度钼的锝-99m 都可以通过 MEK 驱动的溶剂萃取简单地进行萃取。本工作的目的是开发一种溶剂萃取和分离工艺，在微尺度内流化学条件下，分别使用毛细管环和基于膜的分离器，从钼中提取和分离锝。所开发的系统能够通过 ZAIPUT 分离装置在大约 20 分钟内定量和选择性地（经衰变校正的 91.0 ± 1.8%）提取和分离 [Tc]TcONa。总之，我们首次在我们的知识范围内证明了在微尺度内流条件下，基于 MEK 的溶剂萃取工艺从基于钼的液体相中提取锝的高效率。
