阴道毛滴虫对甲硝唑的菌株敏感性研究。
Studies on strain sensitivity of Trichomonas vaginalis to metronidazole.
作者信息
Meingassner J G, Havelec L, Mieth H
出版信息
Br J Vener Dis. 1978 Apr;54(2):72-6. doi: 10.1136/sti.54.2.72.
Abstract
Ninety-four strains of Trichomonas vaginalis isolated from unselected patients in Vienna during the period from November 1975 to November 1975 were subjected to sensitivity tests against metronidazole in vitro and in vivo. Nearly 90% of the isolates examined showed in vitro growth inhibition at concentrations of 0.4 to 1.6 microgram metronidazole/ml and only about 10% at concentrations of less than 0.4 microgram/ml. All isolates showed some inhibition of growth after incubation for 48 hours with 3.2 microgram metroidazole/ml. Tests on treatment carried out on experimentally infected mice revealed that all strains of T. vaginalis examined were sensitive to metronidazole (MDE: less than 3 x 35 mg/kg peroral).
摘要
1975年11月至1975年11月期间，从维也纳未经挑选的患者中分离出94株阴道毛滴虫，对其进行了甲硝唑的体外和体内敏感性测试。近90%的检测分离株在甲硝唑浓度为0.4至1.6微克/毫升时显示体外生长抑制，而在浓度低于0.4微克/毫升时只有约10%。所有分离株在与3.2微克/毫升甲硝唑孵育48小时后均显示出一定的生长抑制。对实验感染小鼠进行的治疗测试表明，所有检测的阴道毛滴虫菌株对甲硝唑敏感（最小有效剂量：口服小于3×35毫克/千克）。
相似文献
1
Studies on strain sensitivity of Trichomonas vaginalis to metronidazole.阴道毛滴虫对甲硝唑的菌株敏感性研究。
Br J Vener Dis. 1978 Apr;54(2):72-6. doi: 10.1136/sti.54.2.72.
2
3
Measuring the in vitro susceptibility of Trichomonas vaginalis to metronidazole: a disk broth method.
Sex Transm Dis. 1980 Jul-Sep;7(3):120-4. doi: 10.1097/00007435-198007000-00005.
4
Susceptibility of Trichomonas vaginalis strains to metronidazole: response to treatment.
Sex Transm Dis. 1983 Jul-Sep;10(3):119-22. doi: 10.1097/00007435-198307000-00003.
5
[Investigation of in vitro metronidazole resistance in the clinical isolates of Trichomonas vaginalis].[阴道毛滴虫临床分离株体外甲硝唑耐药性的研究]
Mikrobiyol Bul. 2016 Oct;50(4):552-558. doi: 10.5578/mb.30140.
6
Metronidazole-resistant Trichomonas vaginalis.甲硝唑耐药阴道毛滴虫
Br J Vener Dis. 1979 Oct;55(5):351-3. doi: 10.1136/sti.55.5.351.
7
Comparative in vitro sensitivity to metronidazole of Trichomonas vaginalis with isolates and clones.阴道毛滴虫分离株和克隆株对甲硝唑的体外敏感性比较。
Southeast Asian J Trop Med Public Health. 1989 Jun;20(2):279-84.
8
Distribution of genotypes in relation to metronidazole susceptibility patterns in Trichomonas vaginalis isolated from South African pregnant women.南非孕妇阴道毛滴虫的基因型分布与甲硝唑敏感性模式的关系。
Parasitol Res. 2021 Jun;120(6):2233-2241. doi: 10.1007/s00436-021-07177-w. Epub 2021 May 18.
9
Strain of Trichomonas vaginalis resistant to metronidazole and other 5-nitroimidazoles.对甲硝唑和其他5-硝基咪唑类药物耐药的阴道毛滴虫菌株。
Antimicrob Agents Chemother. 1979 Feb;15(2):254-7. doi: 10.1128/AAC.15.2.254.
10
A metronidazole-resistant strain of Trichomonas vaginalis and its sensitivity to Go 10213.一株甲硝唑耐药性阴道毛滴虫及其对Go 10213的敏感性
J Antimicrob Chemother. 1984 Oct;14(4):423-6. doi: 10.1093/jac/14.4.423.
引用本文的文献
1
2
In Vitro Susceptibility of Iranian Isolates of Trichomonas vaginalis to Metronidazole.伊朗阴道毛滴虫分离株对甲硝唑的体外敏感性
Iran J Parasitol. 2016 Jan-Mar;11(1):46-51.
3
Molecular epidemiology of metronidazole resistance in a population of Trichomonas vaginalis clinical isolates.阴道毛滴虫临床分离株群体中甲硝唑耐药性的分子流行病学
J Clin Microbiol. 2000 Aug;38(8):3004-9. doi: 10.1128/JCM.38.8.3004-3009.2000.
4
Metronidazole. A therapeutic review and update.甲硝唑：治疗综述与更新
Drugs. 1997 Nov;54(5):679-708. doi: 10.2165/00003495-199754050-00003.
5
Use of a time-kill technique for susceptibility testing of Trichomonas vaginalis.使用时间杀菌技术进行阴道毛滴虫药敏试验。
Antimicrob Agents Chemother. 1985 Mar;27(3):332-6. doi: 10.1128/AAC.27.3.332.
6
In vitro susceptibility of Trichomonas vaginalis to 50 antimicrobial agents.阴道毛滴虫对50种抗菌药物的体外敏感性
Antimicrob Agents Chemother. 1988 Jan;32(1):144-6. doi: 10.1128/AAC.32.1.144.
7
Strain of Trichomonas vaginalis resistant to metronidazole and other 5-nitroimidazoles.对甲硝唑和其他5-硝基咪唑类药物耐药的阴道毛滴虫菌株。
Antimicrob Agents Chemother. 1979 Feb;15(2):254-7. doi: 10.1128/AAC.15.2.254.
本文引用的文献
1
Trichomonal Vaginitis Resistant to Metranidazole.甲硝唑耐药的滴虫性阴道炎
Can Med Assoc J. 1962 Apr 7;86(14):665.
2
Absorption and excretion of metronidazole. II. Studies on primary failures.甲硝唑的吸收与排泄。II. 原发性治疗失败的研究。
Br J Vener Dis. 1961 Dec;37(4):276-7. doi: 10.1136/sti.37.4.276.
3
[PRELIMINARY OBSERVATIONS ON STRAINS OF TRICHOMONAS VAGINALIS NATURALLY RESISTANT TO METRONIDAZOLE].[对天然耐药于甲硝唑的阴道毛滴虫菌株的初步观察]
Arch Ostet Ginecol. 1963 Jul-Aug;68:422-32.
4
Strain sensitivity of Trichomonas vaginalis to metronidazole.阴道毛滴虫对甲硝唑的菌株敏感性。
Br J Vener Dis. 1962 Dec;38(4):218-9. doi: 10.1136/sti.38.4.218.
5
Laboratory studies with the systemic trichomonacide, metronidazole.使用全身性滴虫杀灭剂甲硝唑的实验室研究。
J Clin Pathol. 1961 Jul;14(4):431-5. doi: 10.1136/jcp.14.4.431.
6
[Observations and problems in the treatment of trichomonas vaginitis].[滴虫性阴道炎治疗中的观察与问题]
Ther Umsch. 1966 Sep;23(9):356-9.
7
Metronidazole treatment of trichomonal vaginitis. A comparison of cure rates in 1961 and 1967.
Acta Obstet Gynecol Scand. 1969;48(3):440-5. doi: 10.3109/00016346909156659.
8
Trichomonas vaginalis: resistance to metronidazole.阴道毛滴虫：对甲硝唑的耐药性。
Am J Obstet Gynecol. 1967 Jun 15;98(4):583-5. doi: 10.1016/0002-9378(67)90118-4.
9
Trichomoniasis in a closed community: efficacy of metronidazole.封闭社区中的滴虫病：甲硝唑的疗效
Br Med J. 1971 Jan 23;1(5742):207-9. doi: 10.1136/bmj.1.5742.207.
10
Further observations on strain sensitivity of Trichomonas vaginalis to metronidazole.阴道毛滴虫对甲硝唑菌株敏感性的进一步观察
Br J Vener Dis. 1969 Jun;45(2):161-2. doi: 10.1136/sti.45.2.161.
Zotero 插件