Meingassner J G, Havelec L, Mieth H
Br J Vener Dis. 1978 Apr;54(2):72-6. doi: 10.1136/sti.54.2.72.
Ninety-four strains of Trichomonas vaginalis isolated from unselected patients in Vienna during the period from November 1975 to November 1975 were subjected to sensitivity tests against metronidazole in vitro and in vivo. Nearly 90% of the isolates examined showed in vitro growth inhibition at concentrations of 0.4 to 1.6 microgram metronidazole/ml and only about 10% at concentrations of less than 0.4 microgram/ml. All isolates showed some inhibition of growth after incubation for 48 hours with 3.2 microgram metroidazole/ml. Tests on treatment carried out on experimentally infected mice revealed that all strains of T. vaginalis examined were sensitive to metronidazole (MDE: less than 3 x 35 mg/kg peroral).
1975年11月至1975年11月期间，从维也纳未经挑选的患者中分离出94株阴道毛滴虫，对其进行了甲硝唑的体外和体内敏感性测试。近90%的检测分离株在甲硝唑浓度为0.4至1.6微克/毫升时显示体外生长抑制，而在浓度低于0.4微克/毫升时只有约10%。所有分离株在与3.2微克/毫升甲硝唑孵育48小时后均显示出一定的生长抑制。对实验感染小鼠进行的治疗测试表明，所有检测的阴道毛滴虫菌株对甲硝唑敏感（最小有效剂量：口服小于3×35毫克/千克）。
