CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No.189 Songling Road, Laoshan District, Qingdao 266101, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Int J Mol Sci. 2018 Dec 22;20(1):50. doi: 10.3390/ijms20010050.
Natural rubber is a kind of indispensable biopolymers with great use and strategic importance in human society. However, its production relies almost exclusively on rubber-producing plants , which have high requirements for growth conditions, and the mechanism of natural rubber biosynthesis remains largely unknown. In the past two decades, details of the rubber chain polymerization and proteins involved in natural rubber biosynthesis have been investigated intensively. Meanwhile, omics and other advanced biotechnologies bring new insight into rubber production and development of new rubber-producing plants. This review summarizes the achievements of the past two decades in understanding the biosynthesis of natural rubber, especially the massive information obtained from the omics analyses. Possibilities of natural rubber biosynthesis in vitro or in genetically engineered microorganisms are also discussed.
天然橡胶是一种不可或缺的生物聚合物，在人类社会中具有巨大的用途和战略重要性。然而，它的生产几乎完全依赖于产胶植物，这些植物对生长条件有很高的要求，而天然橡胶生物合成的机制在很大程度上仍然未知。在过去的二十年中，橡胶链聚合的细节以及参与天然橡胶生物合成的蛋白质已经被深入研究。同时，组学和其他先进的生物技术为橡胶生产和新型产胶植物的开发带来了新的见解。本文综述了过去二十年中对天然橡胶生物合成的理解所取得的成就，特别是从组学分析中获得的大量信息。还讨论了在体外或遗传工程微生物中进行天然橡胶生物合成的可能性。
