Rosenthal M
Blut. 1978 Nov 13;37(5):271-4. doi: 10.1007/BF01539663.
Circulating immune complexes were determined utilizing an immunofluorescence technique in sera of 271 healthy donors in different age groups. Practically no immune complexes were detected up to the age of 60. Among the donors ranging in age between 60 and 70 years, 20% revealed immune complexes in their sera. The incidence of circulating immune complexes increased up to 33% among the individuals between 70 and 75 years of age and up to 40% among those over 76 years. In view of earlier findings of decreased numerical and functional capacities of peripheral blood lymphocytes and functional capacities of peripheral blood lymphocytes and increased incidence of auto-antibodies, the observation, that the incidence of circulating immune complexes increases with age seems to support the hypothesis of an age-dependent immunological impairment. To what extent such an immunological insufficiency plays a role in the general aging process remains unknown. It can, however, explain some of the auto-immune diseases seen frequently among the elderly population.
采用免疫荧光技术测定了271名不同年龄组健康供者血清中的循环免疫复合物。在60岁之前几乎未检测到免疫复合物。在60至70岁的供者中，20%的人血清中出现了免疫复合物。70至75岁人群中循环免疫复合物的发生率增至33%，76岁以上人群中则增至40%。鉴于此前有外周血淋巴细胞数量和功能能力下降以及自身抗体发生率增加的研究结果，循环免疫复合物发生率随年龄增长这一观察结果似乎支持了年龄依赖性免疫损伤的假说。这种免疫功能不全在总体衰老过程中起多大作用尚不清楚。然而，它可以解释老年人群中常见的一些自身免疫性疾病。
