口服镁补充剂对 2 型糖尿病患者血糖反应的影响。
The Effects of Oral Magnesium Supplementation on Glycemic Response among Type 2 Diabetes Patients.
机构信息
Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Al-Azhar University-Gaza, Jamal Abdl Naser St., P.O. Box 1277, Gaza, Gaza Strip 00970, Palestine.
出版信息
Nutrients. 2018 Dec 26;11(1):44. doi: 10.3390/nu11010044.
BACKGROUND
Magnesium (Mg) supplementation may help control glycemic response among type 2 diabetes (T2D) patients.
OBJECTIVE
This study means to determine whether Mg supplementation improves glycemic control indicators in patients with T2D.
METHODS
After one week of the dietary stabilization phase, 42 T2D patients were stratified according to sex, age, fasting blood sugar (FBS) and Mg levels and then randomly allocated into two groups. The intervention group was on 250 mg/day of elemental Mg for three months while the control group did not receive any type of supplements throughout the intervention period.
RESULTS
The daily administration of 250 mg of elemental Mg indicated a significant improvement in HbA1C (8.32 to 7.96%, < 0.001), insulin levels (IL) (15.56 to 12.18 μIU/mL, < 0.001), C-peptide (2.28 to 1.90 ng/mL, = 0.001), HOMA.IR (6.16 to 4.44, < 0.001) and HOMA.β% (59.99 to 52.37, = 0.036) of the intervention group when compared with the control group after three months of intervention.
CONCLUSION
The results of this study revealed that oral Mg supplementation reduces insulin resistance and improves the glycemic control indicators among T2D patients.
TRIAL REGISTRATION
current controlled trials PHRC/HC/32/15. Registered 5 October 2015.
背景
镁（Mg）补充可能有助于控制 2 型糖尿病（T2D）患者的血糖反应。
目的
本研究旨在确定 Mg 补充是否改善 T2D 患者的血糖控制指标。
方法
在饮食稳定期一周后，根据性别、年龄、空腹血糖（FBS）和 Mg 水平将 42 名 T2D 患者分层，然后随机分为两组。干预组每天服用 250mg 元素 Mg，持续三个月，而对照组在整个干预期间不接受任何类型的补充。
结果
每天服用 250mg 元素 Mg 可显著改善 HbA1C（8.32 至 7.96%，<0.001）、胰岛素水平（IL）（15.56 至 12.18μIU/mL，<0.001）、C-肽（2.28 至 1.90ng/mL，=0.001）、HOMA.IR（6.16 至 4.44，<0.001）和 HOMA.β%（59.99 至 52.37，=0.036），与对照组相比，干预组在三个月的干预后。
结论
本研究结果表明，口服 Mg 补充可降低胰岛素抵抗并改善 T2D 患者的血糖控制指标。
试验注册
当前对照试验 PHRC/HC/32/15。2015 年 10 月 5 日注册。
Zotero 插件