Hou Ao-Lin, Xu Wen-Dong
Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China,
J Pain Res. 2018 Dec 13;11:3171-3179. doi: 10.2147/JPR.S174663. eCollection 2018.
Neuropathic pain is a common and intractable sequel of brachial plexus injury.
To investigate the underlying mechanisms, we established a unique model of neuropathic pain in rats by creating brachial plexus avulsion injury.
Behavioral test of mechanical stimulation suggested that all rats developed neuropathic pain, and the pain thresholds of bilateral hind limbs significantly decreased. GFAP expression in the cervical spinal cord appeared on day 1 post-injury and increased on day 4. Ionized calcium-binding adaptor molecule 1 expression appeared on day 1 post-injury and increased until day 28. Therefore, the brachial plexus avulsion injury model can imitate the development of neuropathic pain and maintain it.
The activation of astrocyte and microglia in the spinal cord plays a key role in the mechanism and treatment of neuropathic pain.
神经性疼痛是臂丛神经损伤常见且难治的后遗症。
为探究其潜在机制，我们通过制造臂丛神经撕脱伤建立了一种独特的大鼠神经性疼痛模型。
机械刺激行为测试表明所有大鼠均出现神经性疼痛，双侧后肢的痛阈显著降低。损伤后第1天，颈脊髓中胶质纤维酸性蛋白（GFAP）表达出现，并在第4天增加。损伤后第1天，离子钙结合衔接分子1表达出现，并持续增加至第28天。因此，臂丛神经撕脱伤模型可模拟神经性疼痛的发展并维持该状态。
脊髓中星形胶质细胞和小胶质细胞的激活在神经性疼痛的机制和治疗中起关键作用。
