Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Materials Science and Engineering, University of Jinan, Jinan, Shandong 250022, PR China.
Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Materials Science and Engineering, University of Jinan, Jinan, Shandong 250022, PR China.
Spectrochim Acta A Mol Biomol Spectrosc. 2019 Apr 5;212:42-47. doi: 10.1016/j.saa.2018.12.026. Epub 2018 Dec 12.
Hydrazine and its derivatives are one of the most important raw chemical materials that have extensive utilization in many areas. It is also widely applied as pharmaceutical derivatives, such as the antipsychotic drug, anti-infective drug, and antitumor drug. However, hydrazine is a highly toxic reagent which can bring severe damage to human and animals. Herein, we have reported a new benzothiazole substituted naphthalene based probe for hydrazine with huge fluorescence change ratio. The fluorescence change ratio at F/F is up to 200-fold in the presence of hydrazine in 60 min. The probe exhibited negligible cytotoxicity toward HeLa cells and was applied for hydrazine detection successfully in HeLa cells.
水合肼及其衍生物是最重要的基础化工原料之一，在许多领域都有广泛的应用。它也被广泛用作药物衍生物，如抗精神病药物、抗感染药物和抗肿瘤药物。然而，水合肼是一种剧毒试剂，会对人类和动物造成严重损害。在这里，我们报道了一种新的基于苯并噻唑取代萘的探针，用于检测水合肼，具有巨大的荧光变化比率。在存在水合肼的情况下，F/F 的荧光变化比高达 200 倍，在 60 分钟内。该探针对 HeLa 细胞表现出极小的细胞毒性，并成功地应用于 HeLa 细胞中水合肼的检测。
