Students' Research Committee, Department of Clinical Nutrition School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
School of Medicine, Islamic Azad University Medical Branch of Sarab, Sarab, Iran.
Crit Rev Food Sci Nutr. 2020;60(4):584-596. doi: 10.1080/10408398.2018.1545218. Epub 2018 Dec 30.
Several investigations have been reported the beneficial effects of synbiotic in participants with obesity, but these findings have been inconsistent. Therefore, we systematically reviewed available randomized clinical trials (RCTs) to elucidate the overall effects of synbiotic supplementation on anthropometric indices among participants with overweight or obesity. Five electronic databases including PubMed, Scopus, ISI Web of science, Cochrane Library and Google Scholar were searched up to October 2018. All RCTs using synbiotic supplements to treat obesity included in this systematic review and meta-analysis. Weighted mean difference (WMD) was pooled using a random-effects model. The present meta-analysis of 23 randomized trials indicated that supplementation with synbiotic can decrease body weight (WMD: -0.80 kg; 95% CI: -1.56 to -0.03, = 0.04) and WC (WMD: -2.07 cm; 95% CI: -3.11 to -1.03, < 0.001). In contrast, synbiotic did not have favorite effects on BMI (WMD: -0.12 kg/m; 95% CI: -0.40 to 0.16, = 0.39) and body fat (WMD: 0.02%; 95% CI: -1.27 to 1.87, = 0.74) compared with the placebo group. Meta-regression analyses revealed that the dosage of probiotic did not have any effect on anthropometric measures. Based on our findings, modulation of gut microbiota composition through synbiotic supplementation might have modest effects on body weight and waist circumference. In this field, however, our knowledge is progressing.
已有多项研究报道了合生元对肥胖参与者的有益影响，但这些发现并不一致。因此，我们系统地综述了现有的随机对照试验（RCT），以阐明合生元补充剂对超重或肥胖参与者体重指数的总体影响。我们检索了 5 个电子数据库，包括 PubMed、Scopus、ISI Web of Science、Cochrane 图书馆和 Google Scholar，检索截至 2018 年 10 月。本系统评价和荟萃分析纳入了所有使用合生元补充剂治疗肥胖的 RCT。使用随机效应模型汇总加权均数差（WMD）。本次荟萃分析纳入了 23 项随机试验，结果表明，合生元补充剂可降低体重（WMD：-0.80kg；95%CI：-1.56 至 -0.03， = 0.04）和腰围（WMD：-2.07cm；95%CI：-3.11 至 -1.03， < 0.001）。相比之下，与安慰剂组相比，合生元对 BMI（WMD：-0.12kg/m；95%CI：-0.40 至 0.16， = 0.39）和体脂（WMD：0.02%；95%CI：-1.27 至 1.87， = 0.74）没有有利影响。Meta 回归分析表明，益生菌的剂量对人体测量指标没有影响。基于我们的研究结果，通过合生元补充剂调节肠道微生物群组成可能对体重和腰围有一定影响。然而，在这一领域，我们的知识正在不断进步。
