Department of Food Science and Biotechnology, Graduate School, Kyungpook National University, Daegu 41566, Korea.
Food and Bio-Industry Research Institute, Inner Beauty/Antiaging Center, Kyungpook National University, Daegu 41566, Korea.
Nutrients. 2018 Dec 28;11(1):60. doi: 10.3390/nu11010060.
Ultraviolet B (UVB) irradiation is viewed as the principal inducer of skin photo-aging, associated with acceleration of collagen degradation and upregulation of matrix metalloproteinases (MMPs). The ethnic groups of southern/western China use Fuzhuan brick-tea (FBT) as a beverage and as a nutritional supplement. In this study, we scrutinized the antagonistic effects of aqueous extract of Fuzhuan-brick tea (FBTA) on skin photo-aging in UVB-exposed human keratinocyte (HaCaT) cells. FBTA exhibited strong antioxidant activity and quenched UVB-induced generation of cellular reactive oxygen species (ROS) without showing any toxicity. FBTA was capable of combating oxidative stress by augmenting messenger RNA (mRNA) and protein levels of both phase I and phase II detoxifying enzymes, especially heme oxygenase 1 (HO-1), by upregulating the nuclear factor erythroid 2-related factor 2 ()-mediated pathway in HaCaT cells via the phosphorylation of p38 and extracellular signal-regulated kinase (ERK). FBTA also downregulated the expression of matrix metalloproteinase-1 (MMP-1) while upregulating type I procollagen by modulating signaling in UVB-irradiated HaCaT cells. Collectively, our results show that FBTA might be useful as a functional food while being a good candidate in the development of cosmetic products and medicines for the remedy of UVB-induced skin photo-aging.
中波紫外线（UVB）辐射被认为是皮肤光老化的主要诱导因素，与胶原蛋白降解加速和基质金属蛋白酶（MMPs）上调有关。中国南方/西部的少数民族将茯砖茶（FBT）作为饮料和营养补充剂。在这项研究中，我们研究了茯砖茶水溶性提取物（FBTA）对 UVB 暴露的人角质形成细胞（HaCaT）细胞皮肤光老化的拮抗作用。FBTA 表现出很强的抗氧化活性，可淬灭 UVB 诱导的细胞活性氧（ROS）生成，而没有显示出任何毒性。FBTA 通过增强信使 RNA（mRNA）和两种 I 相和 II 相解毒酶的蛋白水平，特别是血红素加氧酶 1（HO-1），从而能够抵抗氧化应激，通过磷酸化 p38 和细胞外信号调节激酶（ERK）来激活核因子红细胞 2 相关因子 2（Nrf2）介导的途径。FBTA 还通过调节 UVB 照射的 HaCaT 细胞中的信号通路，下调基质金属蛋白酶-1（MMP-1）的表达，同时上调 I 型原胶原。总的来说，我们的结果表明，FBTA 可能可用作功能性食品，同时也是开发用于治疗 UVB 诱导的皮肤光老化的化妆品产品和药物的良好候选物。
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