Alkady Manal M, Abdel-Messeih Phebe L, Nosseir Neveen M
Radiation Health Research Department, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt.
J Med Biochem. 2018 Jul 1;37(3):313-319. doi: 10.1515/jomb-2017-0062. eCollection 2018 Jul.
Colorectal cancer (CRC) is one of the most common cancers worldwide. The tumor microenvironment is very important for determining cancer cell growth and spreading. Chemerin, a newly identified adipokine secreted by adipose tissue, is known to be associated with obesity, metabolic syndrome, and insulin resistance. The present study was carried out to investigate the association between serum levels of chemerin and colorectal cancer.
Thirty-two patients with colorectal cancer aged 57.6±6.5 years, and twenty age, sex and BMI matched healthy controls were included in the study. Serum che me rin levels were determined using enzyme linked immuno sorbent assay. C-reactive protein (CRP) levels were determined using a turbidimetric immunoassay. Carcino embryonic antigen (CEA) and carbohydrate antigen (CA 19-9) were measured by radioimmunoassay.
Chemerin levels were found to be significantly higher in patients relative to the controls (P<0.001) and gradually increased with the TNM tumor stage progression. The mean CRP, CEA and CA 19-9 levels were also significantly higher in patients (P<0.001). There was a significant correlation between the serum levels of chemerin and the other measured parameters in CRC patients. The area under receiver operating characteristic curve (ROC) for serum chemerin was 1 at a cut-off value ≥ 161.5 with 100% sensitivity and 100% specificity.
Conclusions: The observed results suggest that chemerin may have a potential role in the pathogenesis and progression of colorectal malignancy and may be a good biomarker of colorectal cancer and stage progression.
结直肠癌（CRC）是全球最常见的癌症之一。肿瘤微环境对于确定癌细胞的生长和扩散非常重要。Chemerin是一种新发现的由脂肪组织分泌的脂肪因子，已知与肥胖、代谢综合征和胰岛素抵抗有关。本研究旨在探讨血清chemerin水平与结直肠癌之间的关联。
本研究纳入了32例年龄为57.6±6.5岁的结直肠癌患者，以及20名年龄、性别和BMI相匹配的健康对照者。采用酶联免疫吸附测定法测定血清chemerin水平。采用比浊免疫测定法测定C反应蛋白（CRP）水平。通过放射免疫测定法测量癌胚抗原（CEA）和糖类抗原（CA 19-9）。
发现患者的chemerin水平显著高于对照组（P<0.001），并随着TNM肿瘤分期进展而逐渐升高。患者的平均CRP、CEA和CA 19-9水平也显著更高（P<0.001）。CRC患者血清chemerin水平与其他测量参数之间存在显著相关性。血清chemerin的受试者工作特征曲线（ROC）下面积在临界值≥161.5时为1，敏感性为100%，特异性为100%。
观察结果表明，chemerin可能在结直肠恶性肿瘤的发病机制和进展中具有潜在作用，可能是结直肠癌和分期进展的良好生物标志物。
