Seo Ji Young, Lee Bong, Kang Tae Woong, Noh Jung Hyun, Kim Min Ju, Ji Yun Bae, Ju Hyeon Jin, Min Byoung Hyun, Kim Moon Suk
1Department of Molecular Science and Technology, Ajou University, 206 Worldcup-ro, Yeongton-gu, Suwon, 16499 Republic of Korea.
2Department of Polymer Engineering, Pukyong National University, 45 Yongso-ro, Nam-Gu, Busan, 48513 Republic of Korea.
Tissue Eng Regen Med. 2018 Aug 9;15(5):513-520. doi: 10.1007/s13770-018-0146-6. eCollection 2018 Oct.
Several injectable hydrogels have been developed extensively for a broad range of biomedical applications. Injectable hydrogels forming through the change in external stimuli have the distinct properties of easy management and minimal invasiveness, and thus provide the advantage of bypassing surgical procedures for administration resulting in better patient compliance.
The injectable -forming hydrogels can be formed irreversibly or reversibly under physiological stimuli. Among several external stimuli that induce formation of hydrogels , in this review, we focused on the electrostatic interactions as the most simple and interesting stimulus.
Currently, numerous polyelectrolytes have been reported as potential electrostatically interactive -forming hydrogels. In this review, a comprehensive overview of the rapidly developing electrostatically interactive -forming hydrogels, which are produced by various anionic and cationic polyelectrolytes such as chitosan, celluloses, and alginates, has been outlined and summarized. Further, their biomedical applications have also been discussed.
The review concludes with perspectives on the future of electrostatically interactive -forming hydrogels.
几种可注射水凝胶已被广泛开发用于广泛的生物医学应用。通过外部刺激变化形成的可注射水凝胶具有易于管理和微创的独特特性，因此具有无需手术给药的优势，从而提高患者的依从性。
可注射成型水凝胶可在生理刺激下不可逆或可逆地形成。在几种诱导水凝胶形成的外部刺激中，在本综述中，我们将重点放在静电相互作用上，因为它是最简单且最有趣的刺激因素。
目前，已有大量聚电解质被报道为潜在的静电相互作用成型水凝胶。在本综述中，已概述并总结了由壳聚糖、纤维素和藻酸盐等各种阴离子和阳离子聚电解质制备的快速发展的静电相互作用成型水凝胶。此外，还讨论了它们的生物医学应用。
本综述最后对静电相互作用成型水凝胶的未来进行了展望。
