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脑库用于神经退行性疾病和衰老的研究。

Brain Banking for Research into Neurodegenerative Disorders and Ageing.

机构信息

Neuroscience Research Australia and the University of New South Wales, Sydney, Australia.

New York University, New York, NY, USA.

出版信息

Neurosci Bull. 2019 Apr;35(2):283-288. doi: 10.1007/s12264-018-0326-3. Epub 2019 Jan 2.

Abstract

Advances in cellular and molecular biology underpin most current therapeutic advances in medicine. Such advances for neurological and neurodegenerative diseases are hindered by the lack of similar specimens. It is becoming increasingly evident that greater access to human brain tissue is necessary to understand both the cellular biology of these diseases and their variation. Research in these areas is vital to the development of viable therapeutic options for these currently untreatable diseases. The development and coordination of human brain specimen collection through brain banks is evolving. This perspective article from the Sydney Brain Bank reviews data concerning the best ways to collect and store material for different research purposes.

摘要

细胞和分子生物学的进展为医学领域的大多数当前治疗进展提供了基础。神经和神经退行性疾病的这些进展受到缺乏类似标本的阻碍。越来越明显的是,需要更多地获取人脑组织,以了解这些疾病的细胞生物学及其变化。这些领域的研究对于为这些目前无法治愈的疾病开发可行的治疗选择至关重要。通过脑库开发和协调人类大脑标本的收集正在发展。这篇来自悉尼脑库的观点文章回顾了有关为不同研究目的收集和存储材料的最佳方法的数据。

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本文引用的文献

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BrainNet Europe's Code of Conduct for brain banking.欧洲脑库脑库行为准则。
J Neural Transm (Vienna). 2015 Jul;122(7):937-40. doi: 10.1007/s00702-014-1353-5. Epub 2015 Jan 13.
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A framework for biobank sustainability.生物样本库可持续性框架。
Biopreserv Biobank. 2014 Feb;12(1):60-8. doi: 10.1089/bio.2013.0064.
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Brain banking: more effective strategies needed.脑库:需要更有效的策略。
Lancet Neurol. 2013 Nov;12(11):1035. doi: 10.1016/S1474-4422(13)70249-7.

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