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三维生物打印:原理、幻想与前景。

3D Bioprinting:principles, fantasies and prospects.

机构信息

Department of maxillofacial and facial plastic surgery, Lyon Sud Hospital, Hospices Civils de Lyon, Claude-Bernard Lyon 1 University, 69310 Pierre-Bénite, France; 3d.FAB platform, ICBMS, CNRS 5246 Claude-Bernard Lyon 1 University, 69100 Villeurbanne, France.

3d.FAB platform, ICBMS, CNRS 5246 Claude-Bernard Lyon 1 University, 69100 Villeurbanne, France.

出版信息

J Stomatol Oral Maxillofac Surg. 2019 Apr;120(2):128-132. doi: 10.1016/j.jormas.2018.12.014. Epub 2019 Jan 1.


DOI:10.1016/j.jormas.2018.12.014
PMID:30609384
Abstract

Conventional three-dimensional (3D) printing techniques have been growing in importance in the field of reconstructive surgery. Three-dimensional bioprinting is the adaptation of 3D printing techniques to tissue engineering, through the use of a bio-ink containing living cells and biomaterials. We hereby describe the principles of bioprinting, its main current limitations, and the prospects of this technique. A PubMed/MEDLINE search was performed. A total of 40 publications were included. To date, most of the tissues have been printed with promising results in vitro (e.g., skin, cartilage, and muscle). The first animal studies are promising for small-scale defects. Vascularization issues are the main limitation to printing large constructs. Once the barrier of vascularization is overcome, printing organs and composite tissues of any size could be possible, opening the doors for personalized medicine based on medical imaging. Printing custom-made autologous grafts or flaps could minimize donor site morbidity and maximize the morphological results. Considering the potential future applications of bioprinting in the field of reconstructive surgery, one has to be aware of this tool, which could drastically change our practice.

摘要

传统的三维(3D)打印技术在重建外科领域的重要性日益增加。三维生物打印是通过使用含有活细胞和生物材料的生物墨水,对 3D 打印技术的一种适应,用于组织工程。我们在此描述生物打印的原理、其主要的当前限制以及该技术的前景。我们进行了 PubMed/MEDLINE 检索。共纳入了 40 篇出版物。迄今为止,大多数组织已在体外打印出有前途的结果(例如皮肤、软骨和肌肉)。对于小范围的缺陷,第一批动物研究结果很有希望。血管化问题是打印大结构的主要限制。一旦克服了血管化的障碍,就有可能打印出任何大小的器官和复合组织,为基于医学成像的个性化医疗开辟道路。打印定制的自体移植物或皮瓣可以最大限度地减少供体部位的发病率,并使形态学结果最大化。考虑到生物打印在重建外科领域的潜在未来应用,人们必须意识到这一工具,它可能会彻底改变我们的实践。

相似文献

[1]
3D Bioprinting:principles, fantasies and prospects.

J Stomatol Oral Maxillofac Surg. 2019-1-1

[2]
[Biofabrication: new approaches for tissue regeneration].

Handchir Mikrochir Plast Chir. 2018-4

[3]
Organ Bioprinting: Are We There Yet?

Adv Healthc Mater. 2017-11-29

[4]
3D printing for clinical application in otorhinolaryngology.

Eur Arch Otorhinolaryngol. 2017-12

[5]
Tissue Engineering Applications of Three-Dimensional Bioprinting.

Cell Biochem Biophys. 2015-7

[6]
Tissue and Organ 3D Bioprinting.

SLAS Technol. 2018-2-23

[7]
3D printing of functional biomaterials for tissue engineering.

Curr Opin Biotechnol. 2016-4-1

[8]
3D Bioprinting Technologies for Tissue Engineering Applications.

Adv Exp Med Biol. 2018

[9]
A Review of 3-Dimensional Skin Bioprinting Techniques: Applications, Approaches, and Trends.

Dermatol Surg. 2020-12

[10]
Recent advances in 3D bioprinting of musculoskeletal tissues.

Biofabrication. 2021-3-10

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[1]
Three-Dimensional Bioprinting and Infertility-Related Female Reproductive System Diseases: A Review of Current and Future Applications.

Tissue Eng Regen Med. 2025-8-19

[2]
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J Maxillofac Oral Surg. 2024-12

[3]
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ACS Omega. 2024-10-25

[4]
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Polymers (Basel). 2024-8-29

[5]
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Sci Rep. 2024-8-1

[6]
Human Induced Pluripotent Spheroids' Growth Is Driven by Viscoelastic Properties and Macrostructure of 3D Hydrogel Environment.

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[7]
Porous biomaterial scaffolds for skeletal muscle tissue engineering.

Front Bioeng Biotechnol. 2023-10-3

[8]
Selection and Optimization of a Bioink Based on PANC-1- Plasma/Alginate/Methylcellulose for Pancreatic Tumour Modelling.

Polymers (Basel). 2023-7-27

[9]
Polysaccharide-based biomaterials in a journey from 3D to 4D printing.

Bioeng Transl Med. 2023-3-22

[10]
A Comprehensive Review of Electrospun Fibers, 3D-Printed Scaffolds, and Hydrogels for Cancer Therapies.

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