Department of maxillofacial and facial plastic surgery, Lyon Sud Hospital, Hospices Civils de Lyon, Claude-Bernard Lyon 1 University, 69310 Pierre-Bénite, France; 3d.FAB platform, ICBMS, CNRS 5246 Claude-Bernard Lyon 1 University, 69100 Villeurbanne, France.
3d.FAB platform, ICBMS, CNRS 5246 Claude-Bernard Lyon 1 University, 69100 Villeurbanne, France.
J Stomatol Oral Maxillofac Surg. 2019 Apr;120(2):128-132. doi: 10.1016/j.jormas.2018.12.014. Epub 2019 Jan 1.
Conventional three-dimensional (3D) printing techniques have been growing in importance in the field of reconstructive surgery. Three-dimensional bioprinting is the adaptation of 3D printing techniques to tissue engineering, through the use of a bio-ink containing living cells and biomaterials. We hereby describe the principles of bioprinting, its main current limitations, and the prospects of this technique. A PubMed/MEDLINE search was performed. A total of 40 publications were included. To date, most of the tissues have been printed with promising results in vitro (e.g., skin, cartilage, and muscle). The first animal studies are promising for small-scale defects. Vascularization issues are the main limitation to printing large constructs. Once the barrier of vascularization is overcome, printing organs and composite tissues of any size could be possible, opening the doors for personalized medicine based on medical imaging. Printing custom-made autologous grafts or flaps could minimize donor site morbidity and maximize the morphological results. Considering the potential future applications of bioprinting in the field of reconstructive surgery, one has to be aware of this tool, which could drastically change our practice.
传统的三维(3D)打印技术在重建外科领域的重要性日益增加。三维生物打印是通过使用含有活细胞和生物材料的生物墨水,对 3D 打印技术的一种适应,用于组织工程。我们在此描述生物打印的原理、其主要的当前限制以及该技术的前景。我们进行了 PubMed/MEDLINE 检索。共纳入了 40 篇出版物。迄今为止,大多数组织已在体外打印出有前途的结果(例如皮肤、软骨和肌肉)。对于小范围的缺陷,第一批动物研究结果很有希望。血管化问题是打印大结构的主要限制。一旦克服了血管化的障碍,就有可能打印出任何大小的器官和复合组织,为基于医学成像的个性化医疗开辟道路。打印定制的自体移植物或皮瓣可以最大限度地减少供体部位的发病率,并使形态学结果最大化。考虑到生物打印在重建外科领域的潜在未来应用,人们必须意识到这一工具,它可能会彻底改变我们的实践。
J Stomatol Oral Maxillofac Surg. 2019-1-1
Handchir Mikrochir Plast Chir. 2018-4
Adv Healthc Mater. 2017-11-29
Eur Arch Otorhinolaryngol. 2017-12
Cell Biochem Biophys. 2015-7
SLAS Technol. 2018-2-23
Curr Opin Biotechnol. 2016-4-1
Adv Exp Med Biol. 2018
Biofabrication. 2021-3-10
J Maxillofac Oral Surg. 2024-12
Polymers (Basel). 2024-8-29
Bioengineering (Basel). 2023-12-13
Front Bioeng Biotechnol. 2023-10-3
Bioeng Transl Med. 2023-3-22
Polymers (Basel). 2022-12-2