From the Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, USA.
J Magn Reson Imaging. 2019 Sep;50(3):824-835. doi: 10.1002/jmri.26631. Epub 2019 Jan 7.
Measuring T in the knee menisci can potentially be used as noninvasive biomarkers in detecting early-stage osteoarthritis (OA).
To demonstrate the feasibility of biexponential T relaxation mapping of human knee menisci.
Prospective.
Eight healthy volunteers with no known inflammation, trauma, or pain in the knee and three symptomatic subjects with early knee OA.
FIELD STRENGTH/SEQUENCE: Customized Turbo-FLASH sequence to acquire 3D-T -weighted images on a 3 T MRI scanner.
T relaxation values were assessed in 11 meniscal regions of interest (ROIs) using monoexponential and biexponential models.
Nonparametric rank-sum tests, Kruskal-Wallis test, and coefficient of variation.
The mean monoexponential T relaxation in the lateral menisci were 28.05 ± 4.2 msec and 37.06 ± 10.64 msec for healthy subjects and early knee OA patients, respectively, while the short and long components were 8.07 ± 0.5 msec and 72.35 ± 3.2 msec for healthy subjects and 2.63 ± 2.99 msec and 55.27 ± 24.76 msec for early knee OA patients, respectively. The mean monoexponential T relaxation in the medial menisci were 34.30 ± 3.8 msec and 37.26 ± 11.38 msec for healthy and OA patients, respectively, while the short and long components were 7.76 ± 0.7 msec and 72.19 ± 4.2 msec for healthy subjects and 3.06 ± 3.24 msec and 55.27 ± 24.59 msec for OA patients, respectively. Statistically significant (P ≤ 0.05) differences were observed in the monoexponential relaxation between some of the ROIs. The T was significantly lower (P = 0.02) in the patients than controls. The rmsCV% ranges were 1.51-16.6%, 3.59-14.3%, and 4.91-15.6% for T -mono, T -short, and T -long, respectively.
Our results showed that in all ROIs, T relaxation times of outer zones (red zones) were less than inner zones (white zones). Monoexponential T was increased in medial, lateral, and body menisci of early OA while the biexponential numbers were decreased in early OA patients.
2 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2019. J. Magn. Reson. Imaging 2019;50:824-835.
在膝关节半月板中测量 T 值可作为早期骨关节炎（OA）检测的无创生物标志物。
证明人体膝关节半月板双指数 T 弛豫映射的可行性。
前瞻性。
8 名志愿者膝关节无炎症、创伤或疼痛，3 名早期膝关节炎患者有症状。
场强/序列：定制 Turbo-FLASH 序列，在 3T MRI 扫描仪上采集 3D-T1 加权图像。
使用单指数和双指数模型评估 11 个半月板感兴趣区（ROI）的 T 弛豫值。
非参数秩和检验、Kruskal-Wallis 检验和变异系数。
外侧半月板的平均单指数 T 弛豫时间分别为健康受试者和早期膝关节炎患者的 28.05±4.2 msec 和 37.06±10.64 msec，短和长分量分别为健康受试者的 8.07±0.5 msec 和 72.35±3.2 msec，以及早期膝关节炎患者的 2.63±2.99 msec 和 55.27±24.76 msec。内侧半月板的平均单指数 T 弛豫时间分别为健康受试者和 OA 患者的 34.30±3.8 msec 和 37.26±11.38 msec，短和长分量分别为健康受试者的 7.76±0.7 msec 和 72.19±4.2 msec，以及 OA 患者的 3.06±3.24 msec 和 55.27±24.59 msec。在一些 ROI 中，单指数弛豫之间观察到统计学显著（P≤0.05）差异。与对照组相比，患者的 T 值显著降低（P=0.02）。T-mon、T-short 和 T-long 的 rmsCV% 范围分别为 1.51-16.6%、3.59-14.3%和 4.91-15.6%。
我们的结果表明，在所有 ROI 中，外区（红区）的 T 弛豫时间小于内区（白区）。内侧、外侧和体部半月板的单指数 T 在早期 OA 中增加，而早期 OA 患者的双指数数量减少。
2 技术功效阶段：1 J. 磁共振成像 2019. J. 磁共振成像 2019；50:824-835.
